Molecular Logic Gates for DNA Analysis: Detection of Rifampin Resistance in M. tuberculosis DNA

被引：41

作者：

Cornett, Evan M. ^{[1
,2
]}

Campbell, Eleanor A. ^{[1
]}

Gulenay, George ^{[2
]}

Peterson, Evan ^{[3
]}

Bhaskar, Neha ^{[3
]}

Kolpashchikov, Dmitry M. ^{[1
,2
]}

机构：

[1] Univ Cent Florida, Dept Chem, Orlando, FL 32816 USA

[2] Univ Cent Florida, Burnett Sch Biomed Sci, Orlando, FL 32816 USA

[3] Lake Highland Preparatory Sch, Orlando, FL USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 36期

基金：

美国国家科学基金会;

关键词：

DNA logic gates; molecular beacon probes; rifampin; SNP analysis; tuberculosis; TIME PCR ASSAY; MYCOBACTERIUM-TUBERCULOSIS; XPERT MTB/RIF; SPECIES IDENTIFICATION; SNP ANALYSIS; PROBE; NANOTECHNOLOGY; PERFORMANCE; COMPUTATION; MUTATIONS;

D O I：

10.1002/anie.201203708

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Elementary, Dr. Watson! A combination of YES and OR logic gates was applied to differentiate between DNA sequences of wild-type and rifampin-resistant (Rifr) Mycobacterium tuberculosis (Mtb) in a multiplex real-time fluorescent assay. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9075 / 9077

页数：3

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