Correlation between carbapenem consumption and resistance to carbapenems among Enterobacteriaceae isolates collected from patients with intra-abdominal infections at five medical centers in Taiwan, 2006-2010

被引：18

作者：

Ho, Cheng-Mao ^{[1
,2
,3
]}

Ho, Mao-Wang ^{[1
,2
,3
]}

Liu, Yung-Ching ^{[4
,5
]}

Toh, Han-Siong ^{[6
,7
]}

Lee, Yu-Lin ^{[8
,9
]}

Liu, Yuag-Meng ^{[3
,8
]}

Huang, Chi-Chang ^{[10
]}

Lug, Po-Liang ^{[11
]}

Liu, Chun-Eng ^{[8
,12
]}

Chen, Yen-Hsu ^{[11
]}

Ko, Wen-Chien ^{[13
,14
]}

Tang, Hung-Jen ^{[15
,16
]}

Yu, Kwok-Woon ^{[17
]}

Chen, Yao-Shen ^{[18
,19
,20
]}

Chuang, Yin-Ching ^{[21
,22
]}

Wang, Jen-Hsien ^{[1
]}

Hsueh, Po-Ren ^{[23
,24
]}

机构：

[1] China Med Univ Hosp, Dept Internal Med, Div Infect Dis, Taichung, Taiwan

[2] China Med Univ Hosp, Dept Lab Med, Taichung, Taiwan

[3] China Med Univ, Grad Inst Clin Med Sci, Taichung, Taiwan

[4] Taipei Med Univ, Shuang Ho Hosp, Dept Internal Med, Div Infect Dis, Taipei, Taiwan

[5] Taipei Med Univ, Coll Med, Sch Med, Dept Internal Med, Taipei, Taiwan

[6] Chi Mei Med Ctr, Dept Infect Dis, Tainan, Taiwan

[7] Chi Mei Hosp, Dept Intens Care, Chiali, Taiwan

[8] Changhua Christian Hosp, Dept Internal Med, Div Infect Dis, Changhua, Taiwan

[9] Natl Yang Ming Univ, Grad Inst Clin Med, Taipei 112, Taiwan

[10] Natl Cheng Kung Univ Hosp, Dept Internal Med, Tainan 70428, Taiwan

[11] Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung, Taiwan

[12] Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan

[13] Natl Cheng Kung Univ, Coll Med, Dept Med, Tainan 70101, Taiwan

[14] Natl Cheng Kung Univ Hosp, Ctr Infect Control, Tainan 70428, Taiwan

[15] Chi Mei Med Ctr, Dept Med, Tainan, Taiwan

[16] Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr, Tainan, Taiwan

[17] Taipei Vet Gen Hosp, Div Infect Dis, Dept Internal Med Pathol & Lab Med, Taipei, Taiwan

[18] Natl Yung Ming Univ, Sch Med, Taipei, Taiwan

[19] Kaohsiung Vet Gen Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung, Taiwan

[20] Natl Kaohsiung Normal Univ, Grad Inst Environm Educ, Kaohsiung, Taiwan

[21] Chi Mei Med Ctr, Dept Internal Med & Med Res, Tainan, Taiwan

[22] Chi Mei Med Ctr, Dept Internal Med, Tainan, Taiwan

[23] Natl Taiwan Univ, Coll Med, Natl Taiwan Univ Hosp, Dept Lab Med, Taipei 100, Taiwan

[24] Natl Taiwan Univ, Coll Med, Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2012年 / 40卷

关键词：

Enterobacteriaceae; Intra-abdominal infections; Carbapenem resistance; Carbapenem consumption; SMART; GRAM-NEGATIVE BACILLI; ASIA-PACIFIC REGION; SPECTRUM-BETA-LACTAMASE; ANTIMICROBIAL RESISTANCE; SMART; EPIDEMIOLOGY; MECHANISMS; DORIPENEM;

D O I：

10.1016/S0924-8579(12)70006-7

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We investigated the trend in resistance to carbapenems among isolates of Enterobacteriaceae that had been collected from patients with intra-abdominal infections at five medical centers in Taiwan from 2006 to 2010 and evaluated the correlation between resistance to carbapenems and consumption of said agents as part of the Study for Monitoring Antimicrobial Resistance Trends (SMART). During the study period, the usage of ertapenem and that of total carbapenems (ertapenem, imipenem, and meropenem) increased significantly from 6.13 to 13.38 defined daily doses per 1000 patient-days for ertapenem and from 20.43 to 34.25 defined daily doses per 1000 patient-days for total carbapenems. The most common species were Escherichia coli (n = 1095), Klebsiella spp. (n = 663), and Enterobacter spp. (n = 202). The susceptibility of all isolates to ertapenem and to imipenem varied during the study period. For ertapenem, the rates of non-susceptibility ranged from 3.5% to 10.3% and those for imipenem ranged from 3.5% to 10.7%. Although the use of carbapenems increased during the study period, there was no marked increase in resistance to carbapenems. Continuous monitoring of resistance trends is necessary so that antimicrobial prescription policies can be adjusted and infection control intervention programs can be implemented. (C) 2012 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：S24 / S28

页数：5

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