共 32 条
Implementation of Proteomics in Clinical Trials
被引:25
作者:

He, Tianlin
论文数: 0 引用数: 0
h-index: 0
机构:
Mosaiques Diagnost GmbH, D-30659 Hannover, Germany
Univ Hosp RWTH Aachen, Inst Mol Cardiovasc Res IMCAR, D-52074 Aachen, Germany Mosaiques Diagnost GmbH, D-30659 Hannover, Germany
机构:
[1] Mosaiques Diagnost GmbH, D-30659 Hannover, Germany
[2] Univ Hosp RWTH Aachen, Inst Mol Cardiovasc Res IMCAR, D-52074 Aachen, Germany
关键词:
clinical trials;
diagnosis;
prognosis;
proteomic;
protein assays;
stratification;
C-REACTIVE PROTEIN;
URINARY PROTEOME;
ANASTOMOTIC LEAK;
BIOMARKERS;
PREDICTORS;
INJURY;
D O I:
10.1002/prca.201800198
中图分类号:
Q5 [生物化学];
学科分类号:
071010 ;
081704 ;
摘要:
The application of protein (or peptide) biomarkers in clinical studies is a dynamic, ever-growing field. The introduction of clinical proteomics/peptidomics, such as mass spectrometry-based assays and multiplexed antibody-based protein arrays, has reshaped the landscape of biomarker identification and validation, allowing the discovery of novel biomarkers at an unprecedented rate and reliability. To reflect the current status with respect to implementation of protein/peptide biomarkers, an investigation of the most recent (last 6 years) clinical studies from clinicaltrials.gov is presented. Forty-two clinical trials involving the direct use of protein or peptide biomarkers in patient stratification and/or disease diagnosis and prognosis are highlighted. Most of the clinical trials that include proteomics/protein assays are aiming toward implementation of non-invasive diagnostic tools for early detection, while many of the clinical trials are targeting to correlate the protein abundance with the risk of a disease event. Less in number are the studies in which the protein biomarkers are applied to stratify the patients for intervention. All the above areas of application are considered of great importance for improving disease management, in an era where implementation toward precision medicine is the desired outcome of proteomics biomarker research.
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Zoidakis, Jerome
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Acad Athens, Biomed Res Fdn, Biotechnol Div, Athens, Greece Univ Leuven, KU Leuven, Studies Coordinating Ctr,Dept Cardiovasc Sci, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium

Droogne, Walter
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h-index: 0
机构:
Univ Hosp Leuven, Div Cardiol, Leuven, Belgium Univ Leuven, KU Leuven, Studies Coordinating Ctr,Dept Cardiovasc Sci, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium

Vlahou, Antonia
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h-index: 0
机构:
Acad Athens, Biomed Res Fdn, Biotechnol Div, Athens, Greece Univ Leuven, KU Leuven, Studies Coordinating Ctr,Dept Cardiovasc Sci, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium

Janssens, Stefan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Leuven, Div Cardiol, Leuven, Belgium Univ Leuven, KU Leuven, Studies Coordinating Ctr,Dept Cardiovasc Sci, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium

Vanhaecke, Johan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Leuven, Div Cardiol, Leuven, Belgium Univ Leuven, KU Leuven, Studies Coordinating Ctr,Dept Cardiovasc Sci, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium

Van Cleemput, Johan
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h-index: 0
机构:
Univ Hosp Leuven, Div Cardiol, Leuven, Belgium Univ Leuven, KU Leuven, Studies Coordinating Ctr,Dept Cardiovasc Sci, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium

Staessen, Jan A.
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h-index: 0
机构:
Univ Leuven, KU Leuven, Studies Coordinating Ctr,Dept Cardiovasc Sci, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium
Maastricht Univ, R&D Grp VitaK, Maastricht, Netherlands Univ Leuven, KU Leuven, Studies Coordinating Ctr,Dept Cardiovasc Sci, Res Unit Hypertens & Cardiovasc Epidemiol, Leuven, Belgium