Highly sensitive determination and selective immobilization of amoxicillin using carbon ionic liquid electrode

被引:19
|
作者
Absalan, Ghodratollah [1 ]
Akhond, Morteza [1 ]
Ershadifar, Hamid [1 ]
机构
[1] Shiraz Univ, Dept Chem, Coll Sci, Prof Massoumi Lab, Shiraz 71454, Iran
关键词
Amoxicillin; Carbon ionic liquid electrode; N-octylpyridinium hexafluorophosphate; Immobilization; VOLTAMMETRIC DETERMINATION; ELECTROCHEMICAL DETECTION; PHENOLIC-COMPOUNDS; SENSOR; NANOPARTICLES; ACID; OXIDATION; FILM;
D O I
10.1007/s10008-015-2894-8
中图分类号
O646 [电化学、电解、磁化学];
学科分类号
081704 ;
摘要
Carbon ionic liquid electrode (CILE) was used as a substrate for immobilization and determination of amoxicillin (AMX) in phosphate buffer solution. The electrochemical response of AMX showed an irreversible oxidation peak in the first scan and redox peaks corresponding to the electrooxidation of product in the subsequent scans which gradually grew upon repetitive scanning. Effect of experimental conditions on electrooxidation of AMX and its adsorbed intermediates was investigated, and possible mechanism for strong immobilization is suggested. The electrode response was linear in the concentration range of 5.0 to 400.0 mu mol L-1 AMX with a detection limit of 0.8 mu mol L-1 AMX. There was no serious interference from other beta-lactam family of antibiotics such as ampicillin and penicillin. The electrode showed good selectivity as well as high sensitivity toward quantification of AMX in pharmaceuticals and urine samples.
引用
收藏
页码:2491 / 2499
页数:9
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