Report of the National Heart, Lung, and Blood Institute Working Group on Epigenetics and Hypertension

被引:75
作者
Cowley, Allen W., Jr. [1 ]
Nadeau, Joseph H. [2 ]
Baccarelli, Andrea [3 ,19 ]
Berecek, Kathleen [4 ]
Fornage, Myriam [5 ]
Gibbons, Gary H. [6 ]
Harrison, David G. [7 ]
Liang, Mingyu
Nathanielsz, Peter W. [8 ]
O'Connor, Daniel T. [9 ]
Ordovas, Jose [10 ,11 ,12 ]
Peng, Weiqun [13 ]
Soares, Marcelo Bento [14 ]
Szyf, Moshe [15 ]
Tolunay, H. Eser [16 ]
Wood, Katherine C. [17 ]
Zhao, Keji [18 ]
Galis, Zorina S. [16 ]
机构
[1] Med Coll Wisconsin, Dept Physiol, Ctr Cardiovasc, Milwaukee, WI 53226 USA
[2] Inst Syst Biol, Seattle, WA USA
[3] Harvard Univ, Sch Publ Hlth, Lab Environm Epigenet, Dept Environm Hlth,Exposure Epidemiol & Risk Prog, Boston, MA 02115 USA
[4] Univ Alabama Birmingham, Dept Physiol & Biophys, Birmingham Comprehens Diabet Ctr, Birmingham, AL USA
[5] Univ Texas Hlth Sci Ctr Houston, Inst Mol Med, Houston, TX USA
[6] Morehouse Sch Med, Cardiovasc Res Inst, Atlanta, GA 30310 USA
[7] Vanderbilt Univ Sch Med, Nashville, TN USA
[8] Univ Texas Hlth Sci Ctr San Antonio, Dept Obstet Gynecol, Ctr Pregnancy & Newborn Res, San Antonio, TX 78229 USA
[9] Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA
[10] Tufts Univ, USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA
[11] Ctr Nacl Invest Cardiovasc, Dept Epidemiol & Populat Genet, Madrid, Spain
[12] IMDEA Alimentac, Madrid, Spain
[13] George Washington Univ, Dept Phys, Washington, DC 20052 USA
[14] Northwestern Univ, Childrens Mem Res Ctr, Falk Brain Tumor Ctr, Chicago, IL 60611 USA
[15] McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ, Canada
[16] NHLBI, Div Cardiovasc Sci, NIH, Bethesda, MD 20892 USA
[17] NHLBI, Hematol Branch, NIH, Bethesda, MD 20892 USA
[18] NHLBI, Div Intramural Res, NIH, Bethesda, MD 20892 USA
[19] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Exposure Epidemiol & Risk Program, Boston, MA 02115 USA
关键词
GENOME-WIDE ASSOCIATION; COMPLEX TRAITS; DISEASE RISK; DEVELOPMENTAL PLASTICITY; MISSING HERITABILITY; PRESSURE; SUSCEPTIBILITY; INHERITANCE; GENE; MECHANISMS;
D O I
10.1161/HYPERTENSIONAHA.111.190116
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
The working group concluded that epigenetics research should incorporate multispecies comparisons to benefit from evolutionary insights and perspectives. Studies will require coordination of multidisciplinary teams combining expertise in clinical and basic research, as well as in computational and modeling methods. New insights and hypotheses will be generated through genomic and epidemiological surveys, including leveraging existing clinical and epidemiological cohorts, experimental animal models, and biological materials to test in new experimental and clinical studies. Study designs will need to be based on sufficient statistical power to handle the likely complexity associated with the heterogeneous causes and consequences of epigenetic changes. Phenotyping at a comparable level of rigor, accuracy, and detail as surveys of epigenetic features will be required. Multiple levels of functionality, from cells to the intact organism, should be studied, and the use of several modalities for inducing experimental hypertension in various model systems would help establish general versus context-specific principles. Finally, such endeavors will require the use and continued development of technologies that enable rigorous and quantitative measures of epigenetic and physiological changes. © 2012 American Heart Association, Inc.
引用
收藏
页码:899 / 905
页数:7
相关论文
共 54 条
[1]   Genetic Mapping in Human Disease [J].
Altshuler, David ;
Daly, Mark J. ;
Lander, Eric S. .
SCIENCE, 2008, 322 (5903) :881-888
[2]  
[Anonymous], 2014, The strategy of the genes
[3]   Cardiovascular Epigenetics Basic Concepts and Results From Animal and Human Studies [J].
Baccarelli, Andrea ;
Rienstra, Michiel ;
Benjamin, Emelia J. .
CIRCULATION-CARDIOVASCULAR GENETICS, 2010, 3 (06) :567-573
[4]   Developmental plasticity and human health [J].
Bateson, P ;
Barker, D ;
Clutton-Brock, T ;
Deb, D ;
D'Udine, B ;
Foley, RA ;
Gluckman, P ;
Godfrey, K ;
Kirkwood, T ;
Lahr, MM ;
McNamara, J ;
Metcalfe, NB ;
Monaghan, P ;
Spencer, HG ;
Sultan, SE .
NATURE, 2004, 430 (6998) :419-421
[5]   Fetal experience and good adult design [J].
Bateson, P .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2001, 30 (05) :928-934
[6]   A decade of exploring the cancer epigenome - biological and translational implications [J].
Baylin, Stephen B. ;
Jones, Peter A. .
NATURE REVIEWS CANCER, 2011, 11 (10) :726-734
[7]   Uncovering the role of 5-hydroxymethylcytosine in the epigenome [J].
Branco, Miguel R. ;
Ficz, Gabriella ;
Reik, Wolf .
NATURE REVIEWS GENETICS, 2012, 13 (01) :7-13
[8]   Genomics Is Not Enough [J].
Chakravarti, Aravinda .
SCIENCE, 2011, 334 (6052) :15-15
[9]   The genetic dissection of essential hypertension [J].
Cowley, Allen W., Jr. .
NATURE REVIEWS GENETICS, 2006, 7 (11) :829-840
[10]   The role of the kidney in hypertension [J].
Cowley, AW ;
Roman, RJ .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1996, 275 (20) :1581-1589