Mitochondrial-Targeted Polyethylenimine Functionalized Graphene Oxide Nanocarrier and its Anti-Tumor Effect on Human Lung Carcinoma Cells

被引：6
作者：
Jin, Mei [1 ,2 ]
Liu, Zhiming [1 ,2 ]
Zhang, Wen [3 ]
Dong, Haixin [1 ,2 ]
Zhou, Fang [1 ,2 ]
Yu, Jianfeng [1 ,2 ]
Wang, Xinpeng [1 ,2 ]
Guo, Zhouyi [1 ,2 ]
机构：
[1] S China Normal Univ, MOE Key Lab Laser Life Sci, Coll Biophoton, Guangzhou 510631, Guangdong, Peoples R China
[2] S China Normal Univ, SATCM Grade Lab Chinese Med & Photon Technol 3, Coll Biophoton, Guangzhou 510631, Guangdong, Peoples R China
[3] S China Univ Technol, Sch Mat Sci & Engn, Guangzhou 510641, Guangdong, Peoples R China
来源：
NANO | 2015年 / 10卷 / 08期
基金：
中国国家自然科学基金; 高等学校博士学科点专项科研基金;
关键词：
Mitochondria-targeting; polyethylenimine; graphene oxide; proton sponge; IN-VIVO; CARBON NANOTUBES; GENE; DELIVERY; CANCER; CYTOTOXICITY; EFFICIENT; TOXICITY; REQUIRES; THERAPY;
D O I：
10.1142/S1793292015501210
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Graphene oxide nanosheet (NGO) was covalently functionalized with positively charged, branched polyethylenimine (bPEI) via an amide bond, coated with serum proteins by electrostatic interaction. Operating as a newly fashioned, multifunctional nanocarrier, the processed NGO showed promise for use in combined gene therapy, chemotherapy, photothermal therapy, bioimaging and as a biosensor of cancer cells. Our current research is focused on the systematic studies of mechanisms of cancer cellular uptake, subcellular location, cytotoxicity and the cellular exclusion of the NGO-bPEI nanocarriers. It was observed that NGO-bPEI accumulated in the mitochondria and that long-term retention of NGO-bPEI led to a decrease in mitochondrial membrane potential while levels of reactive oxygen species increased. The mitochondrial effects
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页数：12
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