Base- Catalyzed N ∼ N Bond Cleavage of Hydrazones: Synthesis of a- Amino Ketones

被引：14

作者：

Tang, Hai-Tao ^{[1
,2
]}

Zhou, Yun-Bing ^{[1
,2
]}

Zhu, Yu ^{[1
,2
]}

Sun, Hong-Chao ^{[1
,2
]}

Lin, Min ^{[1
,2
]}

Zhan, Zhuang-Ping ^{[1
,2
]}

机构：

[1] Xiamen Univ, Coll Chem & Chem Engn, Dept Chem, Xiamen 361005, Fujian, Peoples R China

[2] Xiamen Univ, Coll Chem & Chem Engn, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Fujian, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2014年 / 9卷 / 05期

基金：

中国国家自然科学基金;

关键词：

amino ketones; domino reactions; hydrazones; NN bond cleavage; ASYMMETRIC-SYNTHESIS; FACILE PREPARATION; PEPTIDYL KETONES; MILD CONDITIONS; NITRILES; CONVERSION; N; N-DIMETHYLHYDRAZONES; REARRANGEMENT; TRANSFORMATION; FRAGMENTATION;

D O I：

10.1002/asia.201400037

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient Cs2CO3-promoted synthesis of -amino ketones using hydrazines, aldehydes, and -haloketones as starting materials through a cascade condensation/nucleophilic substitution/NN bond cleavage route is developed. The carbonyl group plays a key role in this novel NN bond cleavage process.

引用

收藏

页码：1278 / 1281

页数：4

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