EFFECT OF AMPHOTERICIN B AND CHITOSAN ON CANDIDA SPP. BIOFILM FORMATION

被引：0

作者：

Kvasnickova, E. ^{[1
]}

Paldrychova, M. ^{[1
]}

Lokocova, K. ^{[1
]}

Masak, J. ^{[1
]}

机构：

[1] Univ Chem & Technol Prague, Tech 5, Prague 16628 6, Czech Republic

来源：

PROCEEDINGS OF THE 5TH INTERNATIONAL CONFERENCE ON CHEMICAL TECHNOLOGY (ICCT) | 2017年

关键词：

PARAPSILOSIS; ALBICANS; KRUSEI;

D O I：

暂无

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Nowadays, antibiotics are often ineffective in biofilm-associated infections treatment. It leads to the use of drugs in higher doses and emergence of related side effects symptoms. This is the reason why researchers are trying to find new alternative substances which are able to overcome this problem. One of the possibly suitable compounds is polysaccharide chitosan, which has significant antimicrobial and also anti-biofilnn properties. This study is focused on the investigation of annphotericin B and polysaccharide chitosan anti-biofilm effect on Candida albicans DBM 2164, Candida parapsilosis DBM 2165 and Candida krusei DBM 2163. We investigated metabolic activity of biofilnns using MTT assay and total biofilnn biomass using crystal violet staining. It was proved that chitosan has significant effect on inhibition of metabolic activity of Candida spp. biofilm cells.

引用

页码：36 / 41

页数：6