Neuroimaging Technological Advancements for Targeting in Functional Neurosurgery

被引：29

作者：

Boutet, Alexandre ^{[1
,2
]}

Gramer, Robert ^{[2
]}

Steele, Christopher J. ^{[3
,4
]}

Elias, Gavin J. B. ^{[2
]}

Germann, Jurgen ^{[2
]}

Maciel, Ricardo ^{[2
,5
]}

Kucharczyk, Walter ^{[1
,2
]}

Zrinzo, Ludvic ^{[6
]}

Lozano, Andres M. ^{[2
]}

Fasano, Alfonso ^{[2
,7
,8
]}

机构：

[1] Univ Toronto, Joint Dept Med Imaging, Toronto, ON, Canada

[2] Univ Hlth Network, Toronto, ON, Canada

[3] Concordia Univ, Dept Psychol, Montreal, PQ, Canada

[4] Max Planck Inst Human Cognit & Brain Sci, Dept Neurol, Leipzig, Germany

[5] UHN Univ Toronto, Toronto Western Hosp, Morton & Gloria Shulman Movement Disorders Clin, Div Neurol,Edmond J Safra Program Parkinsons Dis, Toronto, ON, Canada

[6] UCL, Queen Sq Inst Neurol, Dept Clin & Movement Neurosci, Funct Neurosurg Unit, London, England

[7] Toronto Western Hosp, Movement Disorders Ctr, Krembil Brain Inst, 399 Bathurst St,7McL410, Toronto, ON M5T 2S8, Canada

[8] Ctr Adv Neurotechnol Innovat Applicat CRANIA, Toronto, ON, Canada

来源：

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS | 2019年 / 19卷 / 07期

关键词：

Deep brain stimulation; Functional neurosurgery; MRI; Neuroimaging; DEEP-BRAIN-STIMULATION; SUBTHALAMIC NUCLEUS; PARKINSONS-DISEASE; 7; T; THALAMIC SEGMENTATION; DIRECTIONAL LEADS; MRI; CONNECTIVITY; VISUALIZATION; LOCALIZATION;

D O I：

10.1007/s11910-019-0961-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose of ReviewAblations and particularly deep brain stimulation (DBS) of a variety of CNS targets are established therapeutic tools for movement disorders. Accurate targeting of the intended structure is crucial for optimal clinical outcomes. However, most targets used in functional neurosurgery are sub-optimally visualized on routine MRI. This article reviews recent neuroimaging advancements for targeting in movement disorders.Recent FindingsDedicated MRI sequences can often visualize to some degree anatomical structures commonly targeted during DBS surgery, including at 1.5-T field strengths. Due to recent technological advancements, MR images using ultra-high magnetic field strengths and new acquisition parameters allow for markedly improved visualization of common movement disorder targets. In addition, novel neuroimaging techniques have enabled group-level analysis of DBS patients and delineation of areas associated with clinical benefits. These areas might diverge from the conventionally targeted nuclei and may instead correspond to white matter tracts or hubs of functional networks.SummaryNeuroimaging advancements have enabled improved direct visualization-based targeting as well as optimization and adjustment of conventionally targeted structures.

引用

页数：11

共 101 条

[1] An Assessment of Current Brain Targets for Deep Brain Stimulation Surgery With Susceptibility-Weighted Imaging at 7 Tesla [J].