Deficient mannose-binding lectin-mediated complement activation despite mannose-binding lectin-sufficient genotypes in an outbreak of Legionella pneumophila pneumonia

被引：9
作者：
Herpers, Bjorn L. [1 ]
Yzerman, Ed P. F. [2 ]
de Jong, Ben A. W. [1 ]
Bruin, Jacob P. [2 ]
Lettinga, Kamilla D. [3 ]
Kuipers, Saskia [4 ]
Den Boer, Jeroen W. [2 ,5 ]
van Hannen, Erik J. [1 ]
Rijkers, Ger T. [1 ]
van Velzen-Blad, Heleen [1 ]
de Jongh, Bartelt M. [1 ]
机构：
[1] St Antonius Hosp, Dept Med Microbiol & Immunol, Nieuwegein, Netherlands
[2] Reg Lab Publ Hlth Kennemerland, Haarlem, Netherlands
[3] Univ Amsterdam, Acad Med Ctr, Div Infect Dis Trop Med & AIDS, NL-1105 AZ Amsterdam, Netherlands
[4] Radboud Univ Nijmegen Med Ctr, Dept Med Microbiol, Nijmegen, Netherlands
[5] Municipal Hlth Serv Kennemerland, Haarlem, Netherlands
来源：
HUMAN IMMUNOLOGY | 2009年 / 70卷 / 02期
关键词：
Mannose-binding lectin; Complement; Immunogenetics; Polymorphism; Human studies; Legionellosis; LEGIONNAIRES-DISEASE; FLOWER SHOW; HUMAN SERUM; GENE; INFECTION; VARIANTS; PROTEIN;
D O I：
10.1016/j.humimm.2008.11.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Polymorphisms leading to deficiency of mannose-binding lectin (MBL) are associated with predisposition to infection. However, MBL deficiency can be protective against intracellular pathogens that use MBL to enter host cells. The role of MBL genotype and activity in infection with the intracellular pathogen Legionella pneumophila was studied in a large outbreak of legionellosis at a Dutch flower show. A total of 141 patients, 65 exposed asymptomatic exhibition staff members and 670 unexposed blood bank donors were included for the study of MBL2 genotypes and MBL-mediated complement activation. Genotypic MBL deficiency was equally prevalent in patients and controls. Deficient MBL-mediated complement activation was more prevalent in patients. Even in patients with genotypes that confer MBL Sufficiency, 20.6% lacked MBL-mediated complement activation. In most patients with MBL-sufficient genotypes who lacked MBL-mediated activation at the acute phase of disease, lectin pathway functionality was restored at convalescence. In conclusion, genotypic MBL deficiency was not a risk factor for legionellosis. However, patients with legionellosis displayed deficient MBL-mediated complement activation even with MBL-sufficient genotypes. Together, these genotypical and functional data suggest that the observed deficiency of lectin pathway activation is an effect of legionellosis rather than a risk factor for acquiring it. (c) 2009 Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics.
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收藏
页码：125 / 129
页数：5
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