Exercise Capacity Affects Quality of Life in Patients with Pulmonary Hypertension

被引：61

作者：

Halank, Michael ^{[1
]}

Einsle, Franziska ^{[2
]}

Lehman, Stephanie ^{[3
]}

Bremer, Hinrich ^{[4
]}

Ewert, Ralf ^{[5
]}

Wilkens, Heinrike ^{[6
]}

Meyer, F. Joachim ^{[7
]}

Gruenig, Ekkehard ^{[8
]}

Seyfarth, Hans-Juergen ^{[9
]}

Kolditz, Martin ^{[1
]}

Wieder, Gesine ^{[2
]}

Hoeffken, Gert ^{[1
]}

Koellner, Volker ^{[10
,11
]}

机构：

[1] Tech Univ Dresden, Carl Gustav Carus Univ Hosp, Dept Internal Med 1, D-01309 Dresden, Germany

[2] Tech Univ Dresden, Inst Clin Psychol & Psychotherapy, D-01309 Dresden, Germany

[3] Tech Univ Dresden, Carl Gustav Carus Univ Hosp, Dept Nucl Med, D-01309 Dresden, Germany

[4] Schwarzwald Baar Klinikum, Dept Internal Med, Donaueschingen, Germany

[5] Ernst Moritz Arndt Univ Greifswald, Dept Internal Med B, Greifswald, Germany

[6] Saarland Univ Hosp, Dept Resp Med, Homburg, Saar, Germany

[7] Klinikum Harlaching, Dept Resp Med & Gastroenterol, Div Internal Med, Munich, Germany

[8] Univ Hosp, Thoraxclin, Ctr Pulm Hypertens, Heidelberg, Germany

[9] Univ Hosp, Dept Pulm Med, Leipzig, Germany

[10] Saarland Univ Hosp, Inst Psychoanal Psychotherapy & Psychosomat Med, Homburg, Saar, Germany

[11] Mediclin Bliestal Kliniken, Dept Psychosomat Med, Blieskastel, Germany

来源：

LUNG | 2013年 / 191卷 / 04期

关键词：

Pulmonary arterial hypertension; Chronic thromboembolic pulmonary hypertension; Quality of life; 6-Minute walk distance; Peak oxygen uptake; Anxiety; Depression; ARTERIAL-HYPERTENSION; HOSPITAL ANXIETY; HEALTH SURVEY; INTERVENTION; DEPRESSION; VALIDATION; THERAPY; SF-36;

D O I：

10.1007/s00408-013-9472-6

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The objective of this prospective study was to evaluate the impact of exercise capacity, mental disorders, and hemodynamics on quality-of-life (QoL) parameters in patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). Sixty-three patients with invasively diagnosed PAH (n = 48) or CTEPH (n = 15) underwent a broad panel of assessments, including cardiopulmonary exercise testing (CPET), 6-minute walking distance (6-MWD), World Health Organization functional class (WHO-FC), and assessment of hemodynamics. QoL was evaluated by the 36-item Medical Outcome Study Short Form Health Survey Questionnaire (SF-36). Exercise capacity, hemodynamics, age, gender, and mental disorders (anxiety and depression) were assessed for association with QoL subscores by uni- and multivariate regression analyses. Exercise capacity, WHO-FC, oxygen therapy, symptoms of right heart failure, right atrial pressure, and mental disorders were significantly associated with QoL (p < 0.05). In the stepwise backward selection multivariate analysis, depression remained an independent parameter in seven of eight subscales of the SF-36. Furthermore, peak oxygen uptake (peakVO(2)) during CPET, 6-MWD, anxiety, long-term oxygen therapy, right heart failure, and age remained independent factors for QoL. Hemodynamic parameters at rest did not independently correlate with any domain of the SF-36 QoL subscores. Mental disorders, exercise capacity, long-term oxygen therapy, right heart failure, and age play important role in the quality of life in patients with PAH and CTEPH.

引用

页码：337 / 343

页数：7

共 32 条

[31] THE HOSPITAL ANXIETY AND DEPRESSION SCALE [J].

ZIGMOND, AS ;

SNAITH, RP .

ACTA PSYCHIATRICA SCANDINAVICA, 1983, 67 (06) :361-370

[32] Evaluation of disease-specific health-related quality of life in patients with pulmonary arterial hypertension [J].

Zlupko, Michael ;

Harhay, Michael O. ;

Gallop, Robert ;

Shin, Jennifer ;

Archer-Chicko, Chris ;

Patel, Rajesh ;

Palevsky, Harold I. ;

Taichman, Darren B. .

RESPIRATORY MEDICINE, 2008, 102 (10) :1431-1438

← 1 2 3 4 →