Microvascular Burden and Incident Heart Failure Among Middle-Aged and Older Adults With Type 1 or Type 2 Diabetes

被引:24
作者
Li, Fu-Rong [1 ,2 ,3 ]
Hukportie, Daniel Nyarko [2 ]
Yang, Jing [4 ,5 ]
Yang, Huan-Huan [6 ]
Chen, Guo-Chong [4 ,7 ]
Wu, Xian-Bo [2 ]
机构
[1] Southern Univ Sci & Technol, Shenzhen Key Lab Cardiovasc Hlth & Precis Med, Shenzhen, Peoples R China
[2] Southern Med Univ, Sch Publ Hlth, Dept Epidemiol, Guangzhou, Guangdong, Peoples R China
[3] Southern Univ Sci & Technol, Sch Publ Hlth & Emergency Management, Shenzhen, Peoples R China
[4] Soochow Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Suzhou, Peoples R China
[5] Soochow Univ, Dept Clin Nutr, Affiliated Hosp 1, Suzhou, Peoples R China
[6] Tsinghua Univ, Vanke Sch Publ Hlth, Beijing, Peoples R China
[7] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY USA
基金
中国国家自然科学基金;
关键词
CARDIOVASCULAR EVENTS; EJECTION FRACTION; RISK; COMPLICATIONS; ASSOCIATION; DISEASE; CONSEQUENCES; DYSFUNCTION; DIAGNOSIS; MORTALITY;
D O I
10.2337/dc22-0177
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE To examine the association between microvascular disease (MVD) and risk of heart failure (HF) among individuals with type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS We included 1,713 and 28,624 participants with T1DM and T2DM, respectively, from the UK Biobank who were free of HF during enrollment. MVD burden reflected by the presence of retinopathy, peripheral neuropathy, and chronic kidney disease (CKD) at baseline was prospectively evaluated for the association with incidence of HF. Hazard ratios (HRs) and 95% CIs of HF were estimated by Cox regression models adjusted for multiple traditional risk factors. RESULTS There were 145 and 2,515 incident cases of HF recorded among participants with T1DM and T2DM, respectively, during a median follow-up of 11.5 years. The association between the number of MVD and HF was stronger among participants with T1DM than among those with T2DM (P for interaction <0.001). Compared with participants with no MVD, those with all three MVD had an adjusted HR (95% CI) of 11.37 (5.62, 22.99) in T1DM and 3.66 (2.74, 4.88) in T2DM. In T1DM, HRs (CIs) were 2.69 (1.75, 4.14) for retinopathy, 2.11 (1.38, 3.23) for peripheral neuropathy, and 2.21 (1.53, 3.18) for CKD. The corresponding estimates in T2DM were 1.24 (1.13, 1.36), 1.63 (1.36, 1.96), and 1.73 (1.59, 1.89), respectively. CONCLUSIONS While a heavier burden of MVD was associated with excess risk of HF both in T1DM and T2DM, the association was evidently more pronounced in T1DM.
引用
收藏
页码:2999 / 3006
页数:8
相关论文
共 39 条
[1]   Diabetes mellitus, blood glucose and the risk of heart failure: A systematic review and meta-analysis of prospective studies [J].
Aune, D. ;
Schlesinger, S. ;
Neuenschwander, M. ;
Feng, T. ;
Janszky, I. ;
Norat, T. ;
Riboli, E. .
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2018, 28 (11) :1081-1091
[2]   Microvascular Disease, Peripheral Artery Disease, and Amputation [J].
Beckman, Joshua A. ;
Duncan, Meredith S. ;
Damrauer, Scott M. ;
Wells, Quinn S. ;
Barnett, Joey V. ;
Wasserman, David H. ;
Bedimo, Roger J. ;
Butt, Adeel A. ;
Marconi, Vincent C. ;
Sico, Jason J. ;
Tindle, Hilary A. ;
Bonaca, Marc P. ;
Aday, Aaron W. ;
Freiberg, Matthew S. .
CIRCULATION, 2019, 140 (06) :449-458
[3]   Clinical aspects of heart failure in individuals with diabetes [J].
Bowes, Christa D. ;
Lien, Lillian F. ;
Butler, Javed .
DIABETOLOGIA, 2019, 62 (09) :1529-1538
[4]   Microvascular disease and risk of cardiovascular events among individuals with type 2 diabetes: a population-level cohort study [J].
Brownrigg, Jack R. W. ;
Hughes, Cian O. ;
Burleigh, David ;
Karthikesalingam, Alan ;
Patterson, Benjamin O. ;
Holt, Peter J. ;
Thompson, Matthew M. ;
de Lusignan, Simon ;
Ray, Kausik K. ;
Hinchliffe, Robert J. .
LANCET DIABETES & ENDOCRINOLOGY, 2016, 4 (07) :588-597
[5]   Peripheral neuropathy and the risk of cardiovascular events in type 2 diabetes mellitus [J].
Brownrigg, Jack R. W. ;
de Lusignan, Simon ;
McGovern, Andrew ;
Hughes, Cian ;
Thompson, Matthew M. ;
Ray, Kausik K. ;
Hinchliffe, Robert J. .
HEART, 2014, 100 (23) :1837-+
[6]   The association between physical activity and risk of mortality is modulated by grip strength and cardiorespiratory fitness: evidence from 498 135 UK-Biobank participants [J].
Celis-Morales, Carlos A. ;
Lyall, Donald M. ;
Anderson, Jana ;
Iliodromiti, Stamatina ;
Fan, Yu ;
Ntuk, Uduakobong E. ;
Mackay, Daniel F. ;
Pell, Jill P. ;
Sattar, Naveed ;
Gill, Jason M. R. .
EUROPEAN HEART JOURNAL, 2017, 38 (02) :116-122
[7]   Heart failure in type 2 diabetes: current perspectives on screening, diagnosis and management [J].
Ceriello, Antonio ;
Catrinoiu, Doina ;
Chandramouli, Chanchal ;
Cosentino, Francesco ;
Dombrowsky, Annique Cornelia ;
Itzhak, Baruch ;
Lalic, Nebojsa Malic ;
Prattichizzo, Francesco ;
Schnell, Oliver ;
Seferovic, Petar M. ;
Valensi, Paul ;
Standl, Eberhard .
CARDIOVASCULAR DIABETOLOGY, 2021, 20 (01)
[8]  
Chawla Aastha, 2016, Indian J Endocrinol Metab, V20, P546, DOI 10.4103/2230-8210.183480
[9]   Diabetic retinopathy and risk of heart failure [J].
Cheung, Ning ;
Wang, Jie J. ;
Rogers, Sophie L. ;
Brancati, Frederick ;
Klein, Ronald ;
Sharrett, A. Richey ;
Wong, Tien Y. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 51 (16) :1573-1578
[10]   Survival of patients with a new diagnosis of heart failure: a population based study [J].
Cowie, MR ;
Wood, DA ;
Coats, AJS ;
Thompson, SG ;
Suresh, V ;
Poole-Wilson, PA ;
Sutton, GC .
HEART, 2000, 83 (05) :505-510