Electrolytic deposition of octacalcium phosphate/collagen composite coating on titanium alloy

被引：22

作者：

Miao, Shundong ^{[1
]}

Weng, Wenjian ^{[1
]}

Li, Zhongli ^{[2
]}

Cheng, Kui ^{[1
]}

Du, Piyi ^{[1
]}

Shen, Ge ^{[1
]}

Han, Gaorong ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Mat Sci & Engn, Hangzhou 310027, Zhejiang, Peoples R China

[2] Peoples Liberat Army Gen Hosp, Dept Orthopaed, Beijing 100853, Peoples R China

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2009年 / 20卷 / 01期

基金：

中国国家自然科学基金;

关键词：

I COLLAGEN; BONE; ADHESION; SURFACES; GROWTH;

D O I：

10.1007/s10856-008-3552-9

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Osteointegration of titanium or its alloy with bone can be greatly improved by calcium phosphate coatings, and further enhanced by an extracellular matrix protein layer such as collagen. In this study, an octacalcium phosphate (OCP)/collagen composite coating layer on Ti6Al4V substrate was prepared using electrolytic deposition method. A layer of OCP mineral consisting of flake-like crystals was first formed on the Ti6Al4V substrate. Subsequently, mineralized collagen fibrils were deposited on the former OCP layer. These collagen fibrils were interconnected and well adhered on the OCP layer so that they were immobilized. The microstructure of the composite coating varied with collagen concentration in the electrolyte. This study could offer a possibility of fabricating a desired surface matrix on orthopedic implants to enhance bone formation and fixation of implants.

引用

页码：131 / 134

页数：4

共 15 条

[1] How surface topography relates to materials properties
Assender, H
Bliznyuk, V
Porfyrakis, K
[J]. SCIENCE, 2002, 297 (5583) : 973 - 976
[2] pH distribution around the electrode during electrochemical deposition process for producing bioactive apatite
Ban, S
Maruno, S
[J]. JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS, 1999, 38 (5A): : L537 - L539
[3] Morphology and microstructure of electrochemically deposited calcium phosphates in a modified simulated body fluid
Ban, S
Maruno, S
[J]. BIOMATERIALS, 1998, 19 (14) : 1245 - 1253
[4] Role of material surfaces in regulating bone and cartilage cell response
Boyan, BD
Hummert, TW
Dean, DD
Schwartz, Z
[J]. BIOMATERIALS, 1996, 17 (02) : 137 - 146
[5] A composite coating by electrolysis-induced collagen self-assembly and calcium phosphate mineralization
Fan, YW
Duan, K
Wang, RZ
[J]. BIOMATERIALS, 2005, 26 (14) : 1623 - 1632
[6] Gelatin behaviour in dilute aqueous solution: Designing a nanoparticulate formulation
Farrugia, CA
Groves, MJ
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1999, 51 (06) : 643 - 649
[7] Geissler U, 2000, J BIOMED MATER RES, V51, P752, DOI 10.1002/1097-4636(20000915)51:4<752::AID-JBM25>3.0.CO
[8] 2-7
[9] Formation of bone-like apatite enhanced by hydrolysis of octacalcium phosphate crystals deposited in collagen matrix
Honda, Y.
Kamakura, S.
Sasaki, K.
Suzuki, O.
[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2007, 80B (02) : 281 - 289
[10] Preparation of bone-like composite coating using a modified simulated body fluid with high Ca and P concentrations
Hu, Kai
Yang, Xian-Jin
Cai, Yan-Li
Cui, Zhen-Duo
Wei, Qiang
[J]. SURFACE & COATINGS TECHNOLOGY, 2006, 201 (3-4) : 1902 - 1906

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