Identification of patients at risk of acute rejection by pretransplantation and posttransplantation monitoring of soluble CD30 levels in kidney transplantation

In this study, we investigated the impact of pre- and posttransplantation sCD30 monitoring on early (< 6 months) acute rejection (AR) risk and analyzed the effect of different immunosuppressive regimens on posttransplantation sCD30 levels in kidney recipients. Fifty patients receiving kidney allograft and 10 healthy donors were included in this retrospective cohort study. Eight patients developed biopsy-proven AR (19%). fit pretransplantation samples, patients showed a significantly higher sCD30 than healthy controls. The pretransplantation and posuransplantation (day-15) sCD30 levels were significantly elevated in rejecting patients compared to non-rejecting patients. No significant differences among immunosuppressive regimens were found in posuransplantation sCD30 levels. High pretransplantation and posuransplantation (day 15) sC-D30 levels are associated with increased risk of early AR, and sCD30 can be another toot to evaluate immunological risk prior to kidney transplantation. There was no difference in immunosuppressive regimens used in this study on posuransplantation sCD30 levels at the first month.