In vitro degradation behavior and biocompatibility of Mg-Nd-Zn-Zr alloy by hydrofluoric acid treatment

被引：114
作者：
Mao, Lin [1 ]
Yuan, Guangyin [1 ,2 ]
Niu, Jialin [1 ]
Zong, Yang [1 ]
Ding, Wenjiang [1 ,2 ]
机构：
[1] Shanghai Jiao Tong Univ, Natl Engn Res Ctr Light Alloy Net Forming, Shanghai 200240, Peoples R China
[2] Shanghai Jiao Tong Univ, State Key Lab Met Matrix Composite, Shanghai 200240, Peoples R China
来源：
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2013年 / 33卷 / 01期
基金：
高等学校博士学科点专项科研基金;
关键词：
Magnesium alloy; Fluoride acid treatment; Microstructure; In vitro degradation; Biocompatibility; CORROSION BEHAVIOR; MAGNESIUM ALLOYS; RARE-EARTH; FLUORIDE; ELEMENTS;
D O I：
10.1016/j.msec.2012.08.036
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
In this paper. Mg-Nd-Zn-Zr alloy (denoted as JDBM) coated with hydrofluoric add (HF) chemical conversion film (MgF2) was researched as a potential biodegradable cardiovascular stent material. The microstructures. in vitro degradation and biocompatibility were investigated. The field emission scanning electron microscopy (FE-SEM) and X-ray photoelectron spectroscopy (XPS) showed that a compact MgF2 film was formed on the surface of JDBM. The corrosion rate decreased in artificial plasma from 0.337 to 0.253 mm.y(-1) and the electrochemical measurement demonstrated that the corrosion resistance of JDBM alloy could be obviously improved due to the protective MgF2 film on the surface of the substrate. Meanwhile, the hemolysis ratio of JDBM decreased from 52.0% to 10.1% and the cytotoxicity met the requirement of cellular application after HF treatment. In addition, JDBM and MgF2 film showed good anti-platelet adhesion, which is a very favorable property for implant material in contact with blood directly. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：242 / 250
页数：9
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