Vitamin D Deficiency Is Associated with Severity of Dry Eye Symptoms and Primary Sjogren's Syndrome: A Systematic Review and Meta-Analysis

被引：20

作者：

Kuo, Che-Yuan ^{[1
]}

Huang, Yu-Chen ^{[2
,3
]}

Lin, Ko-Jo ^{[4
,5
]}

Tsai, Tsung-Yu ^{[2
,3
]}

机构：

[1] Taipei Vet Gen Hosp, Dept Ophthalmol, Taipei, Taiwan

[2] Taipei Med Univ, Dept Dermatol, Wan Fang Hosp, Taipei, Taiwan

[3] Taipei Med Univ, Wan Fang Hosp, Res Ctr Big Data & Metaanal, Taipei, Taiwan

[4] Taipei Med Univ, Grad Inst Clin Med, Coll Med, Taipei, Taiwan

[5] Taipei Med Univ, Wan Fang Hosp, Dept Ophthalmol, Taipei, Taiwan

来源：

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY | 2020年 / 66卷 / 04期

关键词：

interleukin; 6; ocular surface disease index; Schirmer's test; tear breakup time; Th1; cells; Th17; SUPPLEMENTATION; DISEASE; IMPACT;

D O I：

10.3177/jnsv.66.386

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

We aimed to examine the correlations between vitamin D deficiency, severity of dry eye symptoms and primary Sjogren's syndrome (pSS) by performing a systematic review and meta-analysis. Online databases (PubMed, Cochrane Library, and Embase) were searched to identify controlled studies comparing (1) severity of dry eye symptoms between participants with and without vitamin D deficiency; and (2) serum vitamin D levels between patients with and without pSS. Eighteen studies were included. Overall, individuals with vitamin D deficiency had shorter tear breakup time (TBUT), lower Schirmer's test scores and higher ocular surface disease index (OSDI) score than those without vitamin D deficiency. Additionally, serum vitamin D levels were found to be lower in pSS than controls. Our findings highlight the importance of vitamin D deficiency in the severity of dry eye symptoms and pSS.

引用

页码：386 / 388

页数：3

共 8 条

[1] Vitamin D Supplementation for Patients with Dry Eye Syndrome Refractory to Conventional Treatment [J].

Bae, Seok Hyun ;

Shin, Young Joo ;

Kim, Ha Kyoung ;

Hyon, Joon Young ;

Wee, Won Ryang ;

Park, Shin Goo .

SCIENTIFIC REPORTS, 2016, 6

[2] Clinical impact of inflammation in dry eye disease: proceedings of the ODISSEY group meeting [J].

Baudouin, Christophe ;

Irkec, Murat ;

Messmer, Elisabeth M. ;

Benitez-del-Castillo, Jose M. ;

Bonini, Stefano ;

Figueiredo, Francisco C. ;

Geerling, Gerd ;

Labetoulle, Marc ;

Lemp, Michael ;

Rolando, Maurizio ;

Van Setten, Gysbert ;

Aragona, Pasquale .

ACTA OPHTHALMOLOGICA, 2018, 96 (02) :111-119

[3] TFOS DEWS II pathophysiology report [J].

Bron, Anthony J. ;

de Paiva, Cintia S. ;

Chauhan, Sunil K. ;

Bonini, Stefano ;

Gabison, Eric E. ;

Jain, Sandeep ;

Knop, Erich ;

Markoulli, Maria ;

Ogawa, Yoko ;

Perez, Victor ;

Uchino, Yuichi ;

Yokoi, Norihiko ;

Zoukhri, Driss ;

Sullivan, David A. .

OCULAR SURFACE, 2017, 15 (03) :438-510

[4] Vitamin D Replacement Improves Tear Osmolarity in Patients with Vitamin D Deficiency [J].

Kizilgu, Muhammed ;

Kan, Seyfullah ;

Ozcelik, Ozgur ;

Beysel, Selvihan ;

Apaydin, Mahmut ;

Ucan, Bekir ;

Caka, Erman .

SEMINARS IN OPHTHALMOLOGY, 2018, 33 (05) :589-594

[5] The association between vitamin D level and Sjogren's syndrome: A meta-analysis [J].

Li, Linhui ;

Chen, Jian ;

Jiang, Yongmei .

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2019, 22 (03) :532-533

[6] The Core Mechanism of Dry Eye Disease Is Inflammation [J].

Wei, Yi ;

Asbell, Penny A. .

EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE, 2014, 40 (04) :248-256

[7] Impact of oral vitamin D supplementation on the ocular surface in people with dry eye and/or low serum vitamin D [J].

Yang, Chih-Huang ;

Albietz, Julie ;

Harkin, Damien G. ;

Kimlin, Michael G. ;

Schmid, Katrina L. .

CONTACT LENS & ANTERIOR EYE, 2018, 41 (01) :69-76

[8] Vitamin D Enhances Corneal Epithelial Barrier Function [J].

Yin, Zhaohong ;

Pintea, Victorina ;

Lin, Yanping ;

Hammock, Bruce D. ;

Watsky, Mitchell A. .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2011, 52 (10) :7359-7364

← 1 →