Genetic and Epigenetic Regulation of Phosphoinositide 3-kinase Isoforms

被引：7
作者：
Fyffe, Chanse [1 ]
Buus, Richard [1 ]
Falasca, Marco [1 ]
机构：
[1] Queen Mary Univ London, Barts & London Sch Med & Dent, Inositide Signalling Grp, Ctr Diabet,Blizard Inst, London E1 2AT, England
来源：
CURRENT PHARMACEUTICAL DESIGN | 2013年 / 19卷 / 04期
关键词：
PI3K; genetic; epigenetic; cancer; SNP; mutations; regulation; PROTEIN-KINASE-B; PHOSPHATIDYLINOSITOL; 3-KINASE; CELL-PROLIFERATION; HIGH-FREQUENCY; PIK3CA GENE; SELECTIVE INHIBITOR; P110-ALPHA ISOFORM; DIFFERENTIAL ROLES; CATALYTIC SUBUNIT; GLUCOSE-TRANSPORT;
D O I：
10.2174/138161213804581873
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The last quarter of a century has witnessed remarkable progress in the understanding of phosphoinositide 3-kinases (PI3K) signalling and their involvement in different diseases such as cancer, diabetes and inflammation. Nevertheless, many questions remain open and among these the role of genetic and epigenetic regulation of PI3K isoforms is one of the most prominent. Emerging evidence Indicates that levels of isoforms can be modulated upon stimulation or in both physiological and pathological conditions including increased gene copy number and transcription regulation. In addition, an intriguing role for epigenetic regulation of PI3K expression, caused by mechanisms other than changes in the underlying DNA sequence, are starting to get appreciated. In this review, we summarize the genetic and epigenetic regulation of PI3Ks in physiology and the role played by their alterations in different diseases.
引用
收藏
页码：680 / 686
页数：7
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