Simvastatin-Loaded β-TCP Drug Delivery System Induces Bone Formation and Prevents Rhabdomyolysis in OVX Mice

被引：8
作者：
Chou, Joshua [1 ]
Ito, Tomoko [2 ]
Otsuka, Makoto [2 ]
Ben-Nissan, Besim [3 ]
Milthorpe, Bruce [4 ]
机构：
[1] Univ Technol Sydney, Sch Med & Mol Sci, Sydney, NSW 2007, Australia
[2] Musashino Univ, Pharmaceut Sci Res Inst, Fac Pharm, Nishi Tokyo 2028585, Japan
[3] Univ Technol Sydney, Sch Chem & Forens Sci, Sydney, NSW 2007, Australia
[4] Univ Technol Sydney, Fac Sci CB04 04 48H, Sydney, NSW 2007, Australia
来源：
ADVANCED HEALTHCARE MATERIALS | 2013年 / 2卷 / 05期
关键词：
controlled drug delivery system; simvastatin; biomaterial; biomimetic; COMBINATION;
D O I：
10.1002/adhm.201200342
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
[No abstract available]
引用
收藏
页码：678 / 681
页数：4
相关论文
共 14 条
[1]  
Ayukawa Y., 2004, CLIN ORAL IMPLAN RES, V404, P343
[2]   Osseointegration in arthroplasty: can simvastatin promote bone response to implants? [J].
Basarir, Kerem ;
Erdemli, Buelent ;
Can, Alp ;
Erdemli, Esra ;
Zeyrek, Tugba .
INTERNATIONAL ORTHOPAEDICS, 2009, 33 (03) :855-859
[3]   Synthesis and characterization of a fluvastatin-releasing hydrogel delivery system to modulate hMSC differentiation and function for bone regeneration [J].
Benoit, Danielle S. W. ;
Nuttelman, Charles R. ;
Collins, Stuart D. ;
Anseth, Kristi S. .
BIOMATERIALS, 2006, 27 (36) :6102-6110
[4]   Targeting and Dissolution Characteristics of Bone Forming and Antibacterial Drugs by Harnessing the Structure of Microspherical Shells from Coral Beach Sand [J].
Chou, Joshua ;
Ben-Nissan, Besim ;
Green, David W. ;
Valenzuela, Stella M. ;
Kohan, Lawrence .
ADVANCED ENGINEERING MATERIALS, 2011, 13 (1-2) :93-99
[5]   Benefit versus risk in statin treatment [J].
Guyton, JR .
AMERICAN JOURNAL OF CARDIOLOGY, 2006, 97 (8A) :95C-97C
[6]   Rhabdomyolysis associated with hydroxymethylglutaryl-coenzyme A reductase inhibitors [J].
Jamal, SM ;
Eisenberg, MJ ;
Christopoulos, S .
AMERICAN HEART JOURNAL, 2004, 147 (06) :956-965
[7]   Effects of Simvastatin on Mandibular Distraction Osteogenesis [J].
Kilic, Erdem ;
Ozec, Ilker ;
Yeler, Hasan ;
Korkmaz, Adnan ;
Ayas, Buelent ;
Gumus, Cesur .
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2008, 66 (11) :2233-2238
[8]   Bone formation with the combination of simvastatin and calcium sulfate in critical-sized rat calvarial defect [J].
Nyan, Myat ;
Sato, Daisuke ;
Oda, Mitsumasa ;
Machida, Tetsu ;
Kobayashi, Hiroshi ;
Nakamura, Takahiro ;
Kasugai, Shohei .
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007, 104 (04) :384-386
[9]   Effects of the combination with α-tricalcium phosphate and simvastatin on bone regeneration [J].
Nyan, Myat ;
Sato, Daisuke ;
Kihara, Hidemichi ;
Machida, Tetsu ;
Ohya, Keiichi ;
Kasugai, Shohei .
CLINICAL ORAL IMPLANTS RESEARCH, 2009, 20 (03) :280-287
[10]  
Özec I, 2007, J CRANIOFAC SURG, V18, P546
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