Identification and Quantification of Proteoforms by Mass Spectrometry

被引：155

作者：

Schaffer, Leah, V ^{[1
]}

Millikin, Robert J. ^{[1
]}

Miller, Rachel M. ^{[1
]}

Anderson, Lissa C. ^{[2
]}

Fellers, Ryan T. ^{[3
]}

Ge, Ying ^{[1
,4
,5
]}

Kelleher, Neil L. ^{[3
,6
,7
]}

LeDuc, Richard D. ^{[3
]}

Liu, Xiaowen ^{[8
,9
]}

Payne, Samuel H. ^{[10
]}

Sun, Liangliang ^{[11
]}

Thomas, Paul M. ^{[3
]}

Tucholski, Trisha ^{[1
]}

Wang, Zhe ^{[12
]}

Wu, Si ^{[12
]}

Wu, Zhijie ^{[1
]}

Yu, Dahang ^{[12
]}

Shortreed, Michael R. ^{[1
]}

Smith, Lloyd M. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

[2] Natl High Magnet Field Lab, Ion Cyclotron Resonance Program, Tallahassee, FL 32310 USA

[3] Northwestern Univ, Prote Ctr Excellence, Evanston, IL 60208 USA

[4] Univ Wisconsin, Dept Cell & Regenerat Biol, Madison, WI 53706 USA

[5] Univ Wisconsin, Human Prote Program, Madison, WI 53706 USA

[6] Northwestern Univ, Dept Chem & Mol Biosci, Evanston, IL 60208 USA

[7] Northwestern Univ, Div Hematol & Oncol, Evanston, IL 60208 USA

[8] Indiana Univ Purdue Univ, Dept BioHlth Informat, Indianapolis, IN 46202 USA

[9] Indiana Univ Sch Med, Ctr Computat Biol & Bioinformat, Indianapolis, IN 46202 USA

[10] Brigham Young Univ, Dept Biol, Provo, UT 84602 USA

[11] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA

[12] Univ Oklahoma, Dept Chem & Biochem, Norman, OK 73019 USA

来源：

PROTEOMICS | 2019年 / 19卷 / 10期

基金：

美国国家卫生研究院;

关键词：

bioinformatics; mass spectrometry; proteoform; proteoform family; top-down proteomics; TOP-DOWN PROTEOMICS; CAPILLARY-ZONE-ELECTROPHORESIS; SIZE-EXCLUSION CHROMATOGRAPHY; LIQUID-CHROMATOGRAPHY; RNA-SEQ; PROTEIN IDENTIFICATION; INTACT-MASS; COMPATIBLE SURFACTANT; DATABASE SEARCH; HIGH-EFFICIENCY;

D O I：

10.1002/pmic.201800361

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A proteoform is a defined form of a protein derived from a given gene with a specific amino acid sequence and localized post-translational modifications. In top-down proteomic analyses, proteoforms are identified and quantified through mass spectrometric analysis of intact proteins. Recent technological developments have enabled comprehensive proteoform analyses in complex samples, and an increasing number of laboratories are adopting top-down proteomic workflows. In this review, some recent advances are outlined and current challenges and future directions for the field are discussed.

引用

页数：15

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