De Novo Design of a Bolaamphiphilic Peptide with Only Natural Amino Acids

被引：34

作者：

Qiu, Feng ^{[1
]}

Chen, Yongzhu ^{[1
]}

Tang, Chengkang ^{[1
]}

Zhou, Qinghan ^{[1
]}

Wang, Chen ^{[4
]}

Shi, Ying-Kang

Zhao, Xiaojun ^{[1
,2
,3
]}

机构：

[1] Sichuan Univ, W China Hosp, Inst Nanobiomed Technol & Membrane Biol, Chengdu 610041, Peoples R China

[2] MIT, Ctr Biomed Engn, Cambridge, MA 02139 USA

[3] Sichuan Univ, W China Hosp, W China Med Sch, Ctr Canc,State Key Lab Biotherapy Human Dis, Chengdu 610041, Peoples R China

[4] Natl Ctr Nanosci & Technol, Beijing 100080, Peoples R China

来源：

MACROMOLECULAR BIOSCIENCE | 2008年 / 8卷 / 11期

关键词：

bolaamphiphilic; nanostructure; peptide; self-assembly; stability;

D O I：

10.1002/mabi.200800180

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new self-assembling bolaamphiphilic peptide has been designed and synthesized using only natural amino acids. This simple peptide is composed of two lysines connected by 4-8 alanines to maintain the characteristics of the traditional bolaamphiphiles. Based on an irregular secondary structure, it can self-assemble into nanospheres, nanorods, or nanofibers with lengths up to micrometers. The long nanofibers can be broken into smaller fragments by sonication, however, they could reassemble into nanofibers after incubation. Furthermore, the nanostructures were shown to have considerable thermostability. This new bolaamphiphilic peptide differs from any other self-assembling peptides or bolaamphiphiles, and possibly provides a new approach to fabricate nanomaterials.

引用

页码：1053 / 1059

页数：7

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