Urinary leukotriene E-4 levels in patients with atopic dermatitis

被引：19

作者：

Sansom, JE ^{[1
]}

Taylor, GW ^{[1
]}

Dollery, CT ^{[1
]}

Archer, CB ^{[1
]}

机构：

[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT CLIN PHARMACOL,LONDON W12 0HS,ENGLAND

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1997年 / 136卷 / 05期

关键词：

D O I：

10.1111/j.1365-2133.1997.tb03674.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Leukotriene synthesis may be increased in a variety of inflammatory diseases. Urinary leukotriene E-4 is a stable metabolite of leukotrienes C-4 and D-4 which has previously been found to be increased in exacerbations of severe asthma and after antigen inhalation. Levels of urinary LTE4 in seven patients during and after a severe flare of atopic dermatitis were measured by high-performance liquid chromatography (HPLC) and radioimmunoassay (RIA). Mean urinary LTE4 levels (+/-SEM) were not increased during (16.7 +/- 3.7 pg/mu mol) or after (16.9 +/- 4.8 pg/mu mol) the acute exacerbation of atopic dermatitis when compared with the normal range (mean = 23.8 [95% confidence interval 19.9-28.2] pg/mu mol creatinine). These findings do not provide evidence of cysteinyl leukotriene involvement in the pathogenesis of atopic dermatitis.

引用

页码：790 / 791

页数：2

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