POLYCYCLIC SYSTEMS CONTAINING 1,2,4-OXADIAZOLE RING 2. 4-(1,2,4-OXADIAZOL-5-YL)PYRROLIDIN-2-ONES: SYNTHESIS AND PREDICTION OF BIOLOGICAL ACTIVITY

被引：7
作者：
Kharchenko, Yu. V. [1 ]
Detistov, O. S. [1 ]
Orlov, V. D. [1 ]
机构：
[1] Kharkov Natl Univ, UA-61077 Kharkov, Ukraine
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2008年 / 44卷 / 05期
关键词：
1,2,4-oxadiazole; pyrrolidin-2-one; biological activity; one-pot synthesis;
D O I：
10.1007/s10593-008-0080-y
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot condensation of 5-oxopyrrolidine-3-carboxylic acids, carbonyldiimidazole, and benzamidoximes leads to the formation of the novel 4-(1,2,4-oxadiazol-5-yl) pyrrolidin-2-one bicyclic systems, the structures of which have been confirmed by IR and (1)H NMR methods and by liquid chromato-mass spectrometry. The results of a PASS prediction of the biological activity of the synthesized compounds are presented.
引用
收藏
页码：600 / 605
页数：6
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