The antitumoral compound Kahalalide F acts on cell lysosomes

被引：79
作者：
GarciaRocha, M
Bonay, P
Avila, J
机构：
[1] Centro de Biología Molecular, Univ. Autónoma de Madrid
来源：
CANCER LETTERS | 1996年 / 99卷 / 01期
关键词：
Kahalalide F; cytoskeleton; lysosomes; Golgi apparatus; endoplasmic reticulum;
D O I：
10.1016/0304-3835(95)04036-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The target for the antitumoral peptidic drug, Kahalalide F, has been studied in cultured cells. In the presence of the compound, the cells became impressively swollen, showing the formation of large vacuoles. The formation of these vacuoles appears to be the consequence of changes in lysosomal membranes. Thus, lysosomes are a target for Kahalalide F action.
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页码：43 / 50
页数：8
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