Preventing stem cell transplantation-associated viral infections using T-cell therapy

被引：0
|
作者：
Tzannou, Ifigeneia [1 ,2 ]
Leen, Ann M. [1 ,2 ]
机构：
[1] Houston Methodist Hosp, Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA
[2] Texas Childrens Hosp, Houston, TX 77030 USA
来源：
IMMUNOTHERAPY | 2015年 / 7卷 / 07期
关键词：
adoptive immunotherapy; hematopoietic stem cell transplantation; T cells; viral infections; RESPIRATORY SYNCYTIAL VIRUS; ALLOGENEIC BONE-MARROW; CORD BLOOD TRANSPLANTATION; DONOR LYMPHOCYTE INFUSION; VERSUS-HOST-DISEASE; EBV-SPECIFIC CTL; LYMPHOPROLIFERATIVE DISEASE; ADOPTIVE IMMUNOTHERAPY; SELECTIVE DEPLETION; SUICIDE-GENE;
D O I：
10.2217/IMT.15.43
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Hematopoietic stem cell transplantation is the treatment of choice for many hematologic malignancies and genetic diseases. However, viral infections continue to account for substantial post-transplant morbidity and mortality. While antiviral drugs are available against some viruses, they are associated with significant side effects and are frequently ineffective. This review focuses on the immunotherapeutic strategies that have been used to prevent and treat infections over the past 20 years and outlines different refinements that have been introduced with the goal of moving this therapy beyond specialized academic centers.
引用
收藏
页码：793 / 810
页数：18
相关论文
共 50 条
  • [1] T-cell therapy: a powerful tool for the management of viral infections and relapse post hematopoietic stem cell transplantation
    Kaloyannidis, Panayotis
    Leen, Ann M.
    Papadopoulou, Anastasia
    EXPERT REVIEW OF HEMATOLOGY, 2012, 5 (05) : 471 - 473
  • [2] Immunotherapy for transplantation-associated viral infections
    Roddie, Claire
    Peggs, Karl S.
    JOURNAL OF CLINICAL INVESTIGATION, 2017, 127 (07) : 2513 - 2522
  • [3] T-cell therapies for leukemia - Preventing recurrence after allogenic stem cell transplantation
    Roessig, C.
    Weber, G.
    Rettinger, E.
    MONATSSCHRIFT KINDERHEILKUNDE, 2010, 158 (03) : 232 - +
  • [4] Adoptive T Cell Therapy Strategies for Viral Infections in Patients Receiving Haematopoietic Stem Cell Transplantation
    Ottaviano, Giorgio
    Chiesa, Robert
    Feuchtinger, Tobias
    Vickers, Mark A.
    Dickinson, Anne
    Gennery, Andrew R.
    Veys, Paul
    Todryk, Stephen
    CELLS, 2019, 8 (01)
  • [5] Virus-Specific T-Cell Therapy for Viral Infections of the Central Nervous System: A Review
    Lambert, Nicolas
    El Moussaoui, Majdouline
    Baron, Frederic
    Maquet, Pierre
    Darcis, Gilles
    VIRUSES-BASEL, 2023, 15 (07):
  • [6] Development of T-cell immunotherapy for hematopoietic stem cell transplantation recipients at risk of leukemia relapse
    Dossa, Robson G.
    Cunningham, Tanya
    Sommermeyer, Daniel
    Medina-Rodriguez, Indira
    Biernacki, Melinda A.
    Foster, Kimberly
    Bleakley, Marie
    BLOOD, 2018, 131 (01) : 108 - 120
  • [7] Harnessing T Cells to Control Infections After Allogeneic Hematopoietic Stem Cell Transplantation
    Basso, Sabrina
    Compagno, Francesca
    Zelini, Paola
    Giorgiani, Giovanna
    Boghen, Stella
    Bergami, Elena
    Bagnarino, Jessica
    Siciliano, Mariangela
    Del Fante, Claudia
    Luppi, Mario
    Zecca, Marco
    Comoli, Patrizia
    FRONTIERS IN IMMUNOLOGY, 2020, 11
  • [8] Risk Factors for Hematopoietic Stem Cell Transplantation-Associated Bone Loss
    Khan, Zehva
    Agarwal, Nidhi B.
    Bhurani, Dinesh
    Khan, Mohd Ashif
    TRANSPLANTATION AND CELLULAR THERAPY, 2021, 27 (03): : 212 - 221
  • [9] Hematopoietic stem cell transplantation and cellular therapy
    Kolb, H. -J.
    HLA, 2017, 89 (05) : 267 - 277
  • [10] T-cell alloreactivity in hematopoietic stem cell transplantation
    Hansen, JA
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2005, 11 (02) : 24 - 27
12345