Pattern of prevalent Hepatitis B virus genotypes in Zaria, Nigeria

被引：14

作者：

Ahmad, Abdurrahman Elfulaty ^{[1
]}

Bakari, Adamu Girei ^{[1
]}

Musa, Bolanle Olufunke Priscilla ^{[1
]}

Mustapha, Shettima Kagu ^{[1
]}

Jamoh, Bello Yusuf ^{[1
]}

Abdullahi, Idris Nasir ^{[2
]}

Tahir, Mohammed Ibrahim ^{[2
]}

Olatunji, Abdulqadri Olarenwaju ^{[5
]}

Maishanu, Sumayya Hamza ^{[5
]}

Suleiman, Ahmed Babangida ^{[3
]}

Tolulope, Afolaranmi ^{[6
]}

Hawkins, Claudia ^{[8
]}

Sagay, Atiene Solomon ^{[7
]}

Zoakah, Ayuba ^{[6
]}

Olayinka, Adebola Tolulope ^{[4
]}

机构：

[1] Ahmadu Bello Univ, Dept Med, Zaria, Nigeria

[2] Ahmadu Bello Univ, Dept Med Lab Sci, Zaria, Nigeria

[3] Ahmadu Bello Univ, Dept Microbiol, Zaria, Nigeria

[4] Ahmadu Bello Univ, Dept Med Microbiol, Zaria, Nigeria

[5] DNA LABS, Res Unit, Kaduna, Nigeria

[6] Univ Jos, Dept Community Med, Jos, Nigeria

[7] Univ Jos, Dept Obstet & Gynaecol, Jos, Nigeria

[8] Northwestern Univ, Dept Med, Feinberg Sch Med, Div Infect Dis, Chicago, IL 60611 USA

来源：

NIGERIAN POSTGRADUATE MEDICAL JOURNAL | 2019年 / 26卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Genotypes; hepatitis B Virus; mixed-infection; Nigeria; Zaria; BLOOD-DONORS; ANTI-HBC; PHYLOGENETIC ANALYSIS; VIRAL-INFECTIONS; SURFACE-ANTIGEN; EPIDEMIOLOGY; WORKERS; AFRICA; TRENDS; HBSAG;

D O I：

10.4103/npmj.npmj_59_19

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Hepatitis B virus (HBV) is hyperendemic in Nigeria. Available literature reveal genotype E as being predominant in West Africa. This study aimed at identifying the current pattern and prevalent genotypes of HBV in Zaria, Nigeria. Materials and Methods: Four millilitre of blood was collected in ethylenediaminetetraacetic acid-container from each of 165 HBV surface antigen-positive participants recruited purposively from the gastroenterology clinic from May to August, 2017. Plasma was separated and frozen at -20 degrees C till analysis. Multiplex-nested polymerase chain reaction using type-specific primers was used to identify the various HBV genotypes. Results: Median (and interquartile range) age of the participants was 31.0 (25.5-39.0) years, with males constituting 107 (64.8%). Majority (83.6%) of the samples analysed were HBV-DNA-positive with 82.6% of the HBV-DNA-positive samples being mixed genotype infections. Irrespective of mode of occurrence, five HBV genotypes were identified with HBV/E (97.1%) being the most predominant, followed by HBV/B (82.6%), HBV/A (24.6%), then HBV/C (17.4%), while HBV/D (0.7%) was the least prevalent. Conclusion: In most (99.1%) of the mixed-infection were a combination of genotype E, the predominant genotype, with other genotypes predominantly genotype B. HBV genotypes E, B, A, C and D are the prevalent genotypes in Zaria, Nigeria, as they occur in single genotype and in mixed-genotypes pattern.

引用

页码：80 / 86

页数：7

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