Chemoimmunomodulation of MDSCs as a novel strategy for cancer therapy

被引：10

作者：

Djeu, Julie ^{[1
]}

Wei, Sheng ^{[1
]}

机构：

[1] Univ S Florida, H Lee Moffitt Canc Ctr, Dept Immunol, Tampa, FL 33682 USA

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 01期

关键词：

myeloid-derived suppressor cells; tumor-associated macrophages; Docetaxel; Icariin; chemoimmunotherapy; tumor microenvironment; apoptosis; SUPPRESSOR-CELLS; DIFFERENTIATION; MACROPHAGES; INHIBITION;

D O I：

10.4161/onci.1.1.18074

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor-induced myeloid-derived suppressor cells (MDSCs) are a critical barrier to effective immunotherapy of cancer. We identified that Docetaxel and a natural compound, Icariin, can target MDSCs with preferential apoptosis of M2 cells and polarization of the surviving cells towards M1 cells. Such strategic targeting of MDSCs restored T cell function accompanied by tumor retardation in vivo.

引用

页码：121 / 122

页数：2

共 10 条

[1] Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein
Cheng, Pingyan
Corzo, Cesar A.
Luetteke, Noreen
Yu, Bin
Nagaraj, Srinivas
Bui, Marylin M.
Ortiz, Myrna
Nacken, Wolfgang
Sorg, Clemens
Vogl, Thomas
Roth, Johannes
Gabrilovich, Dmitry I.
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (10) : 2235 - 2249
[2] Myeloid-derived suppressor cells as regulators of the immune system
Gabrilovich, Dmitry I.
Nagaraj, Srinivas
[J]. NATURE REVIEWS IMMUNOLOGY, 2009, 9 (03) : 162 - 174
[3] A Novel Chemoimmunomodulating Property of Docetaxel: Suppression of Myeloid-Derived Suppressor Cells in Tumor Bearers
Kodumudi, Krithika N.
Woan, Karrune
Gilvary, Danielle L.
Sahakian, Eva
Wei, Sheng
Djeu, Julie Y.
[J]. CLINICAL CANCER RESEARCH, 2010, 16 (18) : 4583 - 4594
[4] Macrophages, innate immunity and cancer: balance, tolerance, and diversity
Mantovani, Alberto
Sica, Antonio
[J]. CURRENT OPINION IN IMMUNOLOGY, 2010, 22 (02) : 231 - 237
[5] Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes
Movahedi, Kiavash
Laoui, Damya
Gysemans, Conny
Baeten, Martijn
Stange, Geert
Van den Bossche, Jan
Mack, Matthias
Pipeleers, Daniel
Veld, Peter In't
De Baetselier, Patrick
Van Ginderachter, Jo A.
[J]. CANCER RESEARCH, 2010, 70 (14) : 5728 - 5739
[6] The Novel Role of Tyrosine Kinase Inhibitor in the Reversal of Immune Suppression and Modulation of Tumor Microenvironment for Immune-Based Cancer Therapies
Ozao-Choy, Junko
Ma, Ge
Kao, Johnny
Wang, George X.
Meseck, Marcia
Sung, Max
Schwartz, Myron
Divino, Celia M.
Pan, Ping-Ying
Chen, Shu-Hsia
[J]. CANCER RESEARCH, 2009, 69 (06) : 2514 - 2522
[7] Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function
Serafini, Paolo
Meckel, Kristen
Kelso, Michael
Noonan, Kimberly
Califano, Joseph
Koch, Wayne
Dolcetti, Luigi
Bronte, Vincenzo
Borrello, Ivan
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (12) : 2691 - 2702
[8] Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity
Suzuki, E
Kapoor, V
Jassar, AS
Kaiser, LR
Albelda, SM
[J]. CLINICAL CANCER RESEARCH, 2005, 11 (18) : 6713 - 6721
[9] Zoledronic acid impairs myeloid differentiation to tumour-associated macrophages in mesothelioma
Veltman, J. D.
Lambers, M. E. H.
van Nimwegen, M.
Hendriks, R. W.
Hoogsteden, H. C.
Hegmans, J. P. J. J.
Aerts, J. G. J. V.
[J]. BRITISH JOURNAL OF CANCER, 2010, 103 (05) : 629 - 641
[10] Icariin and its derivative, ICT, exert anti-inflammatory, anti-tumor effects, and modulate myeloid derived suppressive cells (MDSCs) functions
Zhou, Junmin
Wu, Jinfeng
Chen, Xianghong
Fortenbery, Nicole
Eksioglu, Erika
Kodumudi, Krithika N.
Pk, Epling-Bumette
Dong, Jingcheng
Djeu, Julie Y.
Wei, Sheng
[J]. INTERNATIONAL IMMUNOPHARMACOLOGY, 2011, 11 (07) : 890 - 898

← 1 →