Should elevated beta-HCG levels be an exclusion criteria in clinical trials? A case report of paraneoplastic secretion associated with lung adenocarcinoma

被引：2

作者：

Taverne, J. ^{[1
]}

Delourme, J. ^{[1
,3
]}

Dhalluin, X. ^{[1
]}

Copin, M. -C. ^{[2
,3
]}

Scherpereel, A. ^{[1
,3
]}

Lafitte, J. -J. ^{[1
,3
]}

Cortot, A. B. ^{[1
,3
]}

机构：

[1] CHRU Lille, Hop Calmette, Serv Pneumol & Oncol Thorac, F-59037 Lille, France

[2] CHRU Lille, Inst Pathol, F-59037 Lille, France

[3] Univ Lille Nord De France, F-5900 Lille, France

来源：

REVUE DE PNEUMOLOGIE CLINIQUE | 2013年 / 69卷 / 01期

关键词：

Lung cancer; Adenocarcinoma; Beta HCG; Paraneoplastic syndromes; HUMAN-CHORIONIC-GONADOTROPIN; PLEOMORPHIC CARCINOMA; SUBUNIT; MARKERS; MANAGEMENT; EXPRESSION; MIMICKING; PREGNANCY;

D O I：

10.1016/j.pneumo.2012.12.002

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

We report the case of a 55-year-old woman with pulmonary adenocarcinoma and bone metastases who was diagnosed with paraneoplastic secretion of the beta subunit of human chorionic gonadotropin (beta-HCG) while being screened for inclusion in a clinical trial. Immunohistochemistry analysis of a bone biopsy revealed strong staining of cancer cells with anti-beta HCG antibodies. Serial measurements of circulating Beta HCG seemed to be influenced by antineoptastic treatments, although they were not strictly associated with tumour evolution assessed by CT scans. Little is known about paraneoplastic secretion of beta HCG, although it has been found in 12% to 24% of non-small cell lung cancers. Usefulness of serial measurements of beta HCG for monitoring NSCLC has yet to be demonstrated, but its use as a criterion for inclusion in clinical trials needs to be questioned. (c) 2013 Published by Elsevier Masson SAS.

引用

页码：36 / 40

页数：5

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