A pivotal role of GSK-3 in synaptic plasticity

被引：149
作者：
Bradley, Clarrisa A. [1 ,2 ]
Peineau, Stephane [1 ,5 ,6 ]
Taghibiglou, Changiz [3 ]
Nicolas, Celine S. [1 ]
Whitcomb, Daniel J. [1 ]
Bortolotto, Zuner A. [1 ]
Kaang, Bong-Kiun [2 ]
Cho, Kwangwook [1 ]
Wang, Yu Tian [4 ]
Collingridge, Graham L. [1 ,2 ]
机构：
[1] Univ Bristol, MRC Ctr Synapt Plast, Bristol BS8 1TD, Avon, England
[2] Seoul Natl Univ, Dept Brain & Cognit Sci, Seoul, South Korea
[3] Univ Saskatchewan, Coll Med, Dept Pharmacol, Saskatoon, SK S7N 0W0, Canada
[4] Univ British Columbia, Brain Res Ctr, Vancouver, BC V5Z 1M9, Canada
[5] INSERM, UMR U676, Paris, France
[6] Univ Med Denis Diderot, Paris, France
来源：
FRONTIERS IN MOLECULAR NEUROSCIENCE | 2012年 / 5卷
基金：
英国生物技术与生命科学研究理事会; 英国惠康基金;
关键词：
GSK-3 (glycogen synthase kinase-3); caspase; 3; Akt (PKB; protein kinase B); synaptic plasticity; LTP (long-term potentiation); LTD (long-term depression); AMPAR (AMPA receptor); NMDAR (NMDA receptor); LONG-TERM DEPRESSION; GLYCOGEN-SYNTHASE KINASE-3; AMYLOID PRECURSOR PROTEIN; GAMMA-AMINOBUTYRIC-ACID; AMPA RECEPTOR; NMDA RECEPTOR; TYROSINE PHOSPHORYLATION; INHIBITORY SYNAPSES; GLUTAMATE-RECEPTOR; TAU PHOSPHORYLATION;
D O I：
10.3389/fnmol.2012.00013
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of long-term depression (LTD) that is induced by the synaptic activation of N-methyl-D-aspartate receptors (NMDARs). In the present article we summarize what is currently known concerning the roles of GSK-3 in synaptic plasticity at both glutamatergic and GABAergic synapses. We summarize its role in cognition and speculate on how alterations in the synaptic functioning of GSK-3 may be a major factor in certain neurodegenerative disorders.
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页数：11
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