Host Range Restriction of Epstein-Barr Virus and Related Lymphocryptoviruses

被引：6
作者：
Muehe, Janine
Wang, Fred [1 ]
机构：
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02115 USA
来源：
JOURNAL OF VIROLOGY | 2015年 / 89卷 / 17期
关键词：
HERPESVIRUS PAPIO; ANIMAL-MODEL; IN-VITRO; TRANSFORMATION; LYMPHOCYTES; PROTEINS; SEQUENCE; CHIMPANZEES; LEUKOCYTES; INFECTION;
D O I：
10.1128/JVI.01235-15
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Epstein-Barr-related herpesviruses, or lymphocryptoviruses (LCV), naturally infect humans and nonhuman primates (NHP), but their host range is not well characterized. Using LCV and B cells from multiple species of Hominidae and Cercopithecidae, we show that LCV can immortalize B cells from some nonnative species but that growth transformation is restricted to B cells from their own family of hominoids or Old World NHP, suggesting a high degree of LCV adaptation to their natural primate host.
引用
收藏
页码：9133 / 9136
页数：4
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