A rare case of extraskeletal Ewing's sarcoma arising from the larynx

被引：1

作者：

Kono, Emi ^{[1
]}

Sasaki, Toru ^{[1
]}

Sakaguchi, Mio ^{[2
]}

Takahashi, Satoru ^{[3
]}

Fujii, Hirofumi ^{[4
]}

Yamauchi, Tomohiko ^{[1
]}

Nishino, Hiroshi ^{[1
]}

机构：

[1] Jichi Med Univ, Sch Med, Dept Otolaryngol, 3311-1 Yakushiji, Simotsuke, Tochigi 3290498, Japan

[2] Jichi Med Univ Hosp, Dept Diagnost Pathol, Shimotsuke, Tochigi, Japan

[3] Jichi Med Univ, Sch Med, Radiooncol, Simotsuke, Tochigi, Japan

[4] Jichi Med Univ, Sch Med, Med Oncol, Simotsuke, Tochigi, Japan

来源：

ACTA OTO-LARYNGOLOGICA CASE REPORTS | 2020年 / 5卷 / 01期

关键词：

Extraskeletal Ewing's sarcoma; immunohistochemical staining; fluorescence in situ hybridization; radiotherapy; chemotherapy; TUMORS; HEAD;

D O I：

10.1080/23772484.2020.1776127

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

We report a rare case of extraskeletal Ewing's sarcoma originating from the larynx. This report describes a 20-year-old man with a large laryngeal tumor extending to the left hypopharynx. This was confirmed to be Ewing's sarcoma based on biopsy and fluorescence in situ hybridization (FISH) findings. Surgery was considered to be inappropriate due to the large tumor size. He received one course of VDC-IE (vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide) chemotherapy, but this proved to be ineffective. Radiotherapy at a total dose of 68.4Gy/38 fractions resulted in marked shrinkage of the tumor. The patient is alive 20 months after treatment with no sign of recurrence or metastasis. The highlights of this report are that FISH is important for the early confirmation of a suspected Ewing's sarcoma diagnosis and that the treatment provided is effective for prolonging the survival of a patient with Ewing's sarcoma.

引用

页码：47 / 51

页数：5

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