Stability of 4-DMAP in Solution

被引：0

作者：

Wang, DP ^{[1
]}

Chang, LC ^{[1
]}

Wang, MT ^{[1
]}

机构：

[1] Natl Def Med Ctr, Sch Pharm, Neihu, Taiwan

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2001年 / 27卷 / 09期

关键词：

4-DMAP; HPLC; kinetic; solution; stability;

D O I：

10.1081/DDC-100107682

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A stability-indicating reversed-phase performance liquid chromatographic method was developed for the detection of 4-(N,N-dimethylamino)phenol (4-DMAP) and its degradation products tinder accelerated degradation conditions. The degradation kinetics of 4-DMAP in aqueous solution over a pH range of 1.12-6.05 and its stability in solutions based on propylene glycol or polyethylene glycol 400 were investigated. The observed rate constants were shown to follow apparent first-order kinetics in all cases. The pH rate profile shows that maximum stability of 4-DMAP was observed in the pH range 2.0 to 3.0. Acid/base catalysis of 4-DMAP was not affected by systems of various ionic strengths. Incorporation of nonaqueous propylene glycol or polyethylene glycol 400 in the pH 3.05 solution of 4-DMAP showed an increase in the stability at 55 degrees C +/- 0.5 degreesC.

引用

页码：997 / 1001

页数：5

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[4]

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