Fine structure study on low concentration zinc substituted hydroxyapatite nanoparticles

被引:77
作者
Hu, Wei [1 ]
Ma, Jun [1 ]
Wang, Jianglin [1 ]
Zhang, Shengmin [1 ,2 ,3 ]
机构
[1] Huazhong Univ Sci & Technol, Adv Biomat & Tissue Engn Ctr, Wuhan 430074, Peoples R China
[2] China Korea Ctr Biomat & Nanobiotechnol, Wuhan 430074, Peoples R China
[3] Huazhong Univ Sci & Technol, Dept Biomed Engn, Wuhan 430074, Peoples R China
来源
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2012年 / 32卷 / 08期
基金
中国国家自然科学基金;
关键词
Hydroxyapatite; Zinc; X-ray absorption spectroscopy; Density function theory; HUMAN OSTEOBLASTS; CALCIUM; STRONTIUM; MECHANISM; DIVALENT;
D O I
10.1016/j.msec.2012.07.014
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
The fine structure of zinc substituted hydroxyapatite was studied using experimental analysis and first-principles calculations. The synthetic hydroxyapatite nanoparticles containing low Zn concentration show rod-like morphology. The crystallite sizes and unit-cell volumes tended to decrease with the increased Zn concentration according to X-ray diffraction patterns. The Zn K-edge X-ray absorption spectra and fitting results suggest that the hydroxyapatite doped with 0.1 mole% zinc is different in the zinc coordination environments compared with that containing more zinc. The density function theory calculations were performed on zinc substituted hydroxyapatite. Two mechanisms included replacing calcium by zinc and inserting zinc along the hydroxyl column and were investigated, and the related substitution energies were calculated separately. It is found that the substitution energies are negative and lowest for inserting zinc between the two oxygen atoms along the hydroxyl column (c-axis). Combined with the spectral analysis, it is suggested that the inserting mechanism is favored for low concentration zinc substituted hydroxyapatite. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码:2404 / 2410
页数:7
相关论文
共 35 条
[1]   Biological responses of human osteoblasts and osteoclasts to flame-sprayed coatings of hydroxyapatite and fluorapatite blends [J].
Bhadang, K. A. ;
Holding, C. A. ;
Thissen, H. ;
McLean, K. M. ;
Forsythe, J. S. ;
Haynes, D. R. .
ACTA BIOMATERIALIA, 2010, 6 (04) :1575-1583
[2]   Effects of strontium ranelate administration on bisphosphonate-altered hydroxyapatite: Matrix incorporation of strontium is accompanied by changes in mineralization and microstructure [J].
Busse, B. ;
Jobke, B. ;
Hahn, M. ;
Priemel, M. ;
Niecke, M. ;
Seitz, S. ;
Zustin, J. ;
Semler, J. ;
Amling, M. .
ACTA BIOMATERIALIA, 2010, 6 (12) :4513-4521
[3]   Zn- and Mg-Doped Hydroxyapatite Nanoparticles for Controlled Release of Protein [J].
Dasgupta, Sudip ;
Banerjee, Shashwat S. ;
Bandyopadhyay, Amit ;
Bose, Susmita .
LANGMUIR, 2010, 26 (07) :4958-4964
[4]  
Evis Z., 2010, CERAM INT, V36, P1633
[5]  
Ferraz M P, 2004, J Appl Biomater Biomech, V2, P74
[6]   Unexpected Mechanism of Zn2+ Insertion in Calcium Phosphate Bioceramics [J].
Gomes, Sandrine ;
Nedelec, Jean-Marie ;
Jallot, Edouard ;
Sheptyakov, Denis ;
Renaudin, Guillaume .
CHEMISTRY OF MATERIALS, 2011, 23 (12) :3072-3085
[7]   Bioactive materials for biomedical applications using sol-gel technology [J].
Gupta, Radha ;
Kumar, Ashok .
BIOMEDICAL MATERIALS, 2008, 3 (03)
[8]  
Hench LL, 1998, J AM CERAM SOC, V81, P1705
[9]   Chemical characterization of some substituted hydroxyapatites [J].
Ibrahim, Doreya Mohamed ;
Mostafa, Amany A. ;
Korowash, Sara Ibrahim .
CHEMISTRY CENTRAL JOURNAL, 2011, 5
[10]   First-principles calculations of the elastic properties of hydroxyapatite doped with divalent ions [J].
Kawabata, Kazuhiko ;
Yamamoto, Tomoyuki .
JOURNAL OF THE CERAMIC SOCIETY OF JAPAN, 2010, 118 (1378) :548-549