SelEXSIDE: Fast and Easy Measurement of Multiple-Bond 1H,13C Coupling Constants for Stereochemical Analysis

被引：21

作者：

Butts, Craig P. ^{[1
]}

Heise, Bert ^{[2
]}

Tatolo, Godiraone ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[2] Agilent Technol UK Ltd, Oxford OX5 1QU, England

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 13期

关键词：

CONFIGURATION ANALYSIS; HMBC;

D O I：

10.1021/ol301078q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Long-range H-1,C-13 coupling constants ((n)J(CH)) are underutilized parameters for stereochemical structure determination, primarily because they are not easy to measure. This report describes a rapid and easily interpreted method for the measurement of one or more (n)J(CH) values based on a C-13 band-selective EXSIDE (SelEXSIDE), which reduces experiment times from many hours down to a few minutes while allowing a simple and straightforward readout of (n)J(CH) values from the resulting in-phase doublet signal.

引用

页码：3256 / 3259

页数：4

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