Control of virus-induced lymphoproliferation: Epstein-Barr virus-induced lymphoproliferation and host immunity

被引:15
作者
Rooney, CM
Smith, CA
Heslop, HE
机构
[1] ST JUDE CHILDRENS RES HOSP, DEPT VIROL, MEMPHIS, TN 38105 USA
[2] ST JUDE CHILDRENS RES HOSP, DEPT MOL BIOL, MEMPHIS, TN 38105 USA
来源
MOLECULAR MEDICINE TODAY | 1997年 / 3卷 / 01期
关键词
D O I
10.1016/S1357-4310(96)10054-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Epstein-Barr virus (EBV) is a latent herpesvirus that is associated with a number of tumors, EBV-infected cells show three patterns of latency ranging from type 1, where only one EBV-encoded antigen is expressed, to type 3, where all nine latent cycle proteins encoded by EBV are expressed, Malignancies exhibiting the type 3 latency pattern are highly immunogenic and occur only in immunocompromised patients, It has recently been shown that adoptive immunotherapy with EBV-specific cytotoxic T lymphocytes is an effective therapy for such tumors, Immunotherapy strategies and approaches to increase tumor immunogenicity are slow being evaluated in tumors expressing type 2 latency.
引用
收藏
页码:24 / 30
页数:7
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