Synthesis and antioxidant activities of some new triheterocyclic compounds containing benzimidazole, thiophene, and 1,2,4-triazole rings

被引：59

作者：

Mentese, Emre ^{[1
]}

Yilmaz, Fatih ^{[1
]}

Baltas, Nimet ^{[1
]}

Bekircan, Olcay ^{[2
]}

Kahveci, Bahittin ^{[3
]}

机构：

[1] Recep Tayyip Erdogan Univ, Art & Sci Fac, Dept Chem, Rize, Turkey

[2] Karadeniz Tech Univ, Dept Chem, Fac Arts & Sci, TR-61080 Trabzon, Turkey

[3] Karadeniz Tech Univ, Dept Nutr & Dietet, Fac Hlth Sci, Trabzon, Turkey

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2015年 / 30卷 / 03期

关键词：

1,2,4-Triazole; antioxidant activity; benzimidazole; thiophene; MICROWAVE-ASSISTED SYNTHESIS; DERIVATIVES; RAT;

D O I：

10.3109/14756366.2014.943203

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Various triheterocyclic compounds containing benzimidazole, thiophene, and 1,2,4-triazole rings (3-6) were synthesized and screened for their antioxidant activities. The structures of the synthesized compounds (2-6) were judged by H-1 NMR, C-13 NMR, elemental analysis, and LC-MS spectral data. Antioxidant activities of the synthesized compounds (2-6) were determined with CUPric Reducing Antioxidant Capacity (CUPRAC), ABTS (2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)/persulfate, and DPPH (1,1-diphenyl-2-picrylhydrazyl) assays. Most of the compounds showed a significant antioxidant activity and especially, compound 5c showed very good SC50 value for DPPH method and compound 5h exhibited very high scavenging activity to ABTS method.

引用

页码：435 / 441

页数：7