Synthesis and antioxidant activities of some new triheterocyclic compounds containing benzimidazole, thiophene, and 1,2,4-triazole rings

被引：59
|
作者：
Mentese, Emre [1 ]
Yilmaz, Fatih [1 ]
Baltas, Nimet [1 ]
Bekircan, Olcay [2 ]
Kahveci, Bahittin [3 ]
机构：
[1] Recep Tayyip Erdogan Univ, Art & Sci Fac, Dept Chem, Rize, Turkey
[2] Karadeniz Tech Univ, Dept Chem, Fac Arts & Sci, TR-61080 Trabzon, Turkey
[3] Karadeniz Tech Univ, Dept Nutr & Dietet, Fac Hlth Sci, Trabzon, Turkey
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2015年 / 30卷 / 03期
关键词：
1,2,4-Triazole; antioxidant activity; benzimidazole; thiophene; MICROWAVE-ASSISTED SYNTHESIS; DERIVATIVES; RAT;
D O I：
10.3109/14756366.2014.943203
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Various triheterocyclic compounds containing benzimidazole, thiophene, and 1,2,4-triazole rings (3-6) were synthesized and screened for their antioxidant activities. The structures of the synthesized compounds (2-6) were judged by H-1 NMR, C-13 NMR, elemental analysis, and LC-MS spectral data. Antioxidant activities of the synthesized compounds (2-6) were determined with CUPric Reducing Antioxidant Capacity (CUPRAC), ABTS (2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)/persulfate, and DPPH (1,1-diphenyl-2-picrylhydrazyl) assays. Most of the compounds showed a significant antioxidant activity and especially, compound 5c showed very good SC50 value for DPPH method and compound 5h exhibited very high scavenging activity to ABTS method.
引用
收藏
页码：435 / 441
页数：7
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