Parallel Synthesis of Pyrrolo[3,2-f]quinolines (PQQ Skeleton) Library via a One-Pot Three-Component Reaction under Catalyst-Free Conditions

被引：3

作者：

Ma, Ning ^{[1
]}

Zhang, Mei-Mei ^{[2
]}

Wang, Xiang-Shan ^{[2
]}

机构：

[1] Jiangsu Normal Univ, Key Lab Biotechnol Med Plant Jiangsu Prov, Xuzhou, Jiangsu, Peoples R China

[2] Jiangsu Normal Univ, Sch Chem & Chem Engn, Jiangsu Key Lab Green Synth Funct Mat, Xuzhou 221116, Jiangsu, Peoples R China

来源：

POLYCYCLIC AROMATIC COMPOUNDS | 2016年 / 36卷 / 05期

关键词：

1H-indol-5-amine; catalyst-free; pyrrolo[3; 4-f]quinoline; synthesis; PYRROLOQUINOLINE QUINONE PQQ; COMBINATORIAL SYNTHESIS; EFFICIENT METHOD; DERIVATIVES; HETEROCYCLES; IODINE; GENES; ACID;

D O I：

10.1080/10406638.2015.1046608

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and straightforward synthetic protocol was developed for the diversity-oriented synthesis of 13-aryl-6,13-dihydrochromeno[4,3-b]pyrrolo[3,2-f]quinolin- 12(3H)-one and 10-aryl-3H-furo[3,4-b]pyrrolo[3,2-f]quinolin-9(7H)-one derivatives (PQQ skeleton) in high yields under catalyst-free conditions. This procedure includes a one-pot three-component reaction of aromatic aldehyde, 1H-indol-5-amine, and 1,3-dicarbonyl compounds to generate total of 25-Membered structurally interesting and pharmacologically significant PQQ skeletons for bio-active screening.

引用

页码：683 / 696

页数：14

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