Potential anti-tubercular agents: Hexahydro-3-phenyl indazol-2-yl(pyridin-4-yl)methanones from anti-tubercular drug isoniazid and bis(substituted-benzylidene)cycloalkanones

被引：10

作者：

Napoleon, Ayyakannu Arumugam ^{[1
]}

Khan, Fazlur-Rahman Nawaz ^{[1
,2
]}

Jeong, Euh Duck ^{[2
]}

Chung, Eun Hyuk ^{[2
]}

机构：

[1] VIT Univ, Sch Adv Sci, Div Organ Chem, Organ & Med Chem Res Lab, Vellore 632014, Tamil Nadu, India

[2] Korea Basic Sci Inst, Busan Ctr, Busan 618230, South Korea

来源：

CHINESE CHEMICAL LETTERS | 2015年 / 26卷 / 05期

关键词：

Benzylidene cyclohexanones; Hexahydro-3-phenyl indazol-2-yl(pyridin-4-yl)methanones; Isoniazid; Anti-tubercular activity; ANTIMYCOBACTERIAL ACTIVITY; PHARMACOLOGICAL EVALUATION; PYRAZOLINE DERIVATIVES;

D O I：

10.1016/j.cclet.2015.01.008

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of indazol-2-yl(pyridin-4-yOmethanones, 4 were acquired from 2,6-bisbenzylidene cyclohex-anones, 3 and anti-tubercular drug (isoniazid), and their anti-tubercular impacts were screened. Among the test compounds used against Mycobacterium tuberculosis H37 Ra cell line in the microplate alamar blue assay, the compounds 4g-j revealed moderate anti-tubercular activity with MIC 12.5 mu g/mL, comparable to standard drugs (streptomycin, MIC, 6.25 mu g/mL, pyrazinamide, isoniazid and ciprofloxacin with MICs of 3.125 mu g/mL). (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：567 / 571

页数：5

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