Biocompatibility of Polyglycidol with Human Peripheral Blood Mononuclear Cells

被引：9

作者：

Huang, Yi-Chun ^{[1
]}

Royappa, A. Timothy ^{[2
]}

Tundel, Sofia ^{[1
]}

Tsukamoto, Kana ^{[1
]}

Sharma, Venkatanarayanan ^{[1
]}

机构：

[1] Univ W Florida, Dept Biol, Lab Cytokine Res, Pensacola, FL 32514 USA

[2] Univ W Florida, Dept Chem, Pensacola, FL 32514 USA

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2009年 / 111卷 / 05期

关键词：

polyglycidol; PBMC; drug delivery; toxicity; polyethers; DRUG-DELIVERY; IN-VITRO; DENDRIMERS; TOXICITY; PROTEINS; POLYMERS; GLYCOL;

D O I：

10.1002/app.29269

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Polyglycidol (PGly), a hyperbranched water-soluble polyether with numerous terminal hydroxyl groups, has structural similarities with polyethylene glycol. Our laboratory is exploring drug delivery using hyperbranched PGly-cytokines conjugates. Using human peripheral blood mononuclear cells and a tumor derived human B cell line, HBL-1; various PGly concentrations were tested for cytotoxicity. Our data indicated that hyperbranched PGly was similar in toxicity to PEG 8000, a commercial polymer. It was concluded that hyperbranched PGly did not exhibit significant cytotoxicity and showed promise for use as a biocompatible polymer. (C) 2008 Wiley Periodicals, Inc. J Appl Polym Sci 111: 2275-2278, 2009

引用

页码：2275 / 2278

页数：4

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