Functional classification of memory CD8+ T cells by CX3CR1 expression

被引：200

作者：

Boettcher, Jan P. ^{[1
]}

Beyer, Marc ^{[2
]}

Meissner, Felix ^{[3
]}

Abdullah, Zeinab ^{[1
]}

Sander, Jil ^{[2
]}

Hoechst, Bastian ^{[4
]}

Eickhoff, Sarah ^{[1
]}

Rieckmann, Jan C. ^{[3
]}

Russo, Caroline ^{[5
]}

Bauer, Tanja ^{[5
]}

Flecken, Tobias ^{[6
]}

Giesen, Dominik ^{[6
]}

Engel, Daniel ^{[1
]}

Jung, Steffen ^{[7
]}

Busch, Dirk H. ^{[8
]}

Protzer, Ulrike ^{[5
]}

Thimme, Robert ^{[6
]}

Mann, Matthias ^{[3
]}

Kurts, Christian ^{[1
]}

Schultze, Joachim L. ^{[2
]}

Kastenmueller, Wolfgang ^{[1
]}

Knolle, Percy A. ^{[1
,4
]}

机构：

[1] Univ Klinikum Bonn, Inst Expt Immunol, D-53105 Bonn, Germany

[2] Univ Bonn, LIMES Inst, Genom & Immunoregulat, D-53115 Bonn, Germany

[3] Max Planck Inst Biochem, D-82152 Martinsried, Germany

[4] Tech Univ Munich, Inst Mol Immunol & Expt Oncol, D-81675 Munich, Germany

[5] Tech Univ Munich, Inst Virol, D-81675 Munich, Germany

[6] Univ Freiburg Klinikum, Clin Internal Med 2, D-79106 Freiburg, Germany

[7] Weizmann Inst Sci, IL-76100 Rehovot, Israel

[8] Tech Univ Munich, Inst Microbiol Immunol & Hyg, D-81675 Munich, Germany

来源：

NATURE COMMUNICATIONS | 2015年 / 6卷

关键词：

CHRONIC VIRAL-INFECTION; FRACTALKINE RECEPTOR CX(3)CR1; DENDRITIC CELLS; LYMPH-NODES; NETWORK VISUALIZATION; SELECTIVE EXPRESSION; LINEAGE RELATIONSHIP; TRANSCRIPTION FACTOR; PROTECTIVE IMMUNITY; IL-7; RECEPTOR;

D O I：

10.1038/ncomms9306

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Localization of memory CD8(+) T cells to lymphoid or peripheral tissues is believed to correlate with proliferative capacity or effector function. Here we demonstrate that the fractalkine-receptor/CX(3)CR1 distinguishes memory CD8(+) T cells with cytotoxic effector function from those with proliferative capacity, independent of tissue-homing properties. CX(3)CR1-based transcriptome and proteome-profiling defines a core signature of memory CD8(+) T cells with effector function. We find CD62L(hi)CX(3)CR1(+) memory T cells that reside within lymph nodes. This population shows distinct migration patterns and positioning in proximity to pathogen entry sites. Virus-specific CX(3)CR1(+) memory CD8(+) T cells are scarce during chronic infection in humans and mice but increase when infection is controlled spontaneously or by therapeutic intervention. This CX3CR1-based functional classification will help to resolve the principles of protective CD8(+) T-cell memory.

引用

页数：17

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