Multi-Path Dilated Residual Network for Nuclei Segmentation and Detection

被引:41
作者
Wang, Eric Ke [1 ]
Zhang, Xun [1 ]
Pan, Leyun [2 ]
Cheng, Caixia [2 ]
Dimitrakopoulou-Strauss, Antonia [2 ]
Ni, Yueping [3 ]
Zhe, Nie [3 ]
机构
[1] Harbin Inst Technol, Shenzhen 518055, Peoples R China
[2] German Canc Res Ctr, D-69120 Heidelberg, Germany
[3] Shenzhen Polytech, Sch Comp Engn, Shenzhen 518055, Peoples R China
基金
中国国家自然科学基金;
关键词
nuclei segmentation; microscopic pathological images observation; object detection; deep learning;
D O I
10.3390/cells8050499
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
As a typical biomedical detection task, nuclei detection has been widely used in human health management, disease diagnosis and other fields. However, the task of cell detection in microscopic images is still challenging because the nuclei are commonly small and dense with many overlapping nuclei in the images. In order to detect nuclei, the most important key step is to segment the cell targets accurately. Based on Mask RCNN model, we designed a multi-path dilated residual network, and realized a network structure to segment and detect dense small objects, and effectively solved the problem of information loss of small objects in deep neural network. The experimental results on two typical nuclear segmentation data sets show that our model has better recognition and segmentation capability for dense small targets.
引用
收藏
页数:19
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