Microencapsulation of cells in alginate through an electrohydrodynamic process

被引：40
|
作者：
Gasperini, L. [1 ,2 ]
Maniglio, D. [1 ,2 ,3 ]
Migliaresi, C. [1 ,2 ,3 ]
机构：
[1] Univ Trent, Biotech Res Ctr, Dept Ind Engn, I-38123 Trento, Italy
[2] European Inst Excellence Tissue Engn & Regenerat, Trento, Italy
[3] INSTM Consorzio Interuniv Nazl Sci & Tecnol Mat, Florence, Italy
来源：
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | 2013年 / 28卷 / 05期
关键词：
microencapsulation; cell encapsulation; Electrohydrodynamic process; alginate; electrospray; cell release; MICROCAPSULES; ENCAPSULATION; ELECTROSPRAY; BIOCOMPATIBILITY; TRANSPLANTATION; TECHNOLOGY; POLYMERS; RICH;
D O I：
10.1177/0883911513501599
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The encapsulation of living cells within a semi-permeable matrix is an attractive process for transplanting nonautologous cells by limiting the interaction with the host immune system. The electrohydrodynamic process is a low-cost and high-throughput system to encapsulate cells by means of a static potential. We evaluated the use of this system for cell entrapment by assessing and then manufacturing capsules that had the best dimensions. The effect of different cell densities on the beads was determined to set up the basic parameters of the encapsulation system. The cell viability inside the beads and as a function of release time was observed for their biological response.
引用
收藏
页码：413 / 425
页数：13
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