Caffeic acid phenethyl ester improves oxidative erythrocyte damage in a rat model of thermal injury

被引：15

作者：

Armutcu, F ^{[1
]}

Gürel, A ^{[1
]}

Hosnuter, M ^{[1
]}

Pabuçcu, O ^{[1
]}

Altinyazar, C ^{[1
]}

机构：

[1] Zonguldak Karaelmas Univ, Dept Biochem & Clin Biochem, Fac Med, TR-67600 Zonguldak, Turkey

来源：

JOURNAL OF BURN CARE & REHABILITATION | 2004年 / 25卷 / 02期

关键词：

D O I：

10.1097/01.BCR.0000111765.08625.D4

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Oxygen-derived free radicals impair cell membrane functions and induce circulatory disturbances, and free radicals, such as superoxide anion, hydrogen peroxide, hydroxyl radicals, and peroxynitrite, have been suggested to play important roles in the pathogenesis of major burn injuries. The present study investigated the effects of thermal injury on erythrocyte lipid peroxidation and antioxidant status and investigated the effects of caffeic acid phenethyl ester (CA-PE), a new antioxidant and anti-inflammatory agent, in rats subjected to thermal injury. Burn injury caused a remarkable increase in erythrocyte lipid peroxidation, levels of nitric oxide (NO), and activities of antioxidant enzymes and xanthine oxidase (XO). The treatment with CAPE decreased both activity of burn-induced XO activity and levels of NO in the erythrocytes. In conclusion, CAPE treatment resulted in decreased erythrocyte lipid peroxidation in thermal injury and helped to prevent oxidative damage by decreasing activity of XO and levels of NO.

引用

页码：171 / 178

页数：8

共 54 条

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