Varicose veins combined with mucoid degeneration of the venous wall

We report on a 56-year-old woman with bilateral chronic venous insufficiency, a cavernous hemangioma at the right thigh and an aneurysm of the left femoral vein, without bone or soft tissue hypertrophy. Histopathology revealed a mucoid degeneration of the media musculature of the venous wall. Such a finding has not yet been described in the world literature. The differential diagnosis must consider a secondary hitherto unknown alteration of varicose veins, a variety of a vascular malformation not yet described, and a primary degeneration of the smooth muscles of the vascular wall followed by the development of varicose veins.