One-pot total chemical synthesis of human α-synuclein

被引：31
|
作者：
Fauvet, Bruno [1 ]
Butterfield, Sara M. [1 ]
Fuks, Jonas [1 ]
Brik, Ashraf [2 ]
Lashuel, Hilal A. [1 ]
机构：
[1] Ecole Polytech Fed Lausanne, CH-1015 Lausanne, Switzerland
[2] Ben Gurion Univ Negev, Dept Chem, IL-84105 Beer Sheva, Israel
来源：
CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 81期
基金：
瑞士国家科学基金会; 欧洲研究理事会;
关键词：
POSTTRANSLATIONAL MODIFICATIONS; PARKINSONS-DISEASE; FMOC-SPPS; LIGATION; PROTEINS; DESULFURIZATION; SEMISYNTHESIS; PATHOGENESIS; AGGREGATION; CYSTEINE;
D O I：
10.1039/c3cc45353g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson's disease-associated pre-synaptic protein alpha-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein.
引用
收藏
页码：9254 / 9256
页数：3
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