One-pot total chemical synthesis of human α-synuclein

被引：31

作者：

Fauvet, Bruno ^{[1
]}

Butterfield, Sara M. ^{[1
]}

Fuks, Jonas ^{[1
]}

Brik, Ashraf ^{[2
]}

Lashuel, Hilal A. ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, CH-1015 Lausanne, Switzerland

[2] Ben Gurion Univ Negev, Dept Chem, IL-84105 Beer Sheva, Israel

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 81期

基金：

瑞士国家科学基金会; 欧洲研究理事会;

关键词：

POSTTRANSLATIONAL MODIFICATIONS; PARKINSONS-DISEASE; FMOC-SPPS; LIGATION; PROTEINS; DESULFURIZATION; SEMISYNTHESIS; PATHOGENESIS; AGGREGATION; CYSTEINE;

D O I：

10.1039/c3cc45353g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson's disease-associated pre-synaptic protein alpha-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein.

引用

页码：9254 / 9256

页数：3

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