Metabolism of high density lipoprotein subfractions

被引:40
|
作者
Colvin, PL
Parks, JS
机构
[1] Vet Affairs Med Ctr, Ctr Geriatr Res Educ & Clin, Baltimore, MD 21201 USA
[2] Univ Maryland, Sch Med, Dept Internal Med, Baltimore, MD 21201 USA
[3] Univ Maryland, Sch Med, Div Gerontol, Baltimore, MD 21201 USA
[4] Wake Forest Univ, Sch Med, Dept Pathol, Winston Salem, NC 27109 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1097/00041433-199908000-00004
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Over the past few years, new experimental approaches have reinforced the awareness among investigators that the heterogeneity of HDL particles indicates significant differences in production and catabolism of HDL particles. Recent kinetic studies have suggested that small HDL, containing two apolipoprotein A-I molecules per particle, are converted in a unidirectional manner to medium HDL or large HDL, containing three or four apolipoprotein A-I molecules per particle, respectively, Conversion appears to occur in close physical proximity with cells and not while HDL particles circulate in plasma, The medium and large HDL are terminal particles in HDL metabolism with large HDL, and perhaps medium HDL, being catabolized primarily by the liver. These novel kinetic studies of HDL subfraction metabolism are compelling in-vivo data that are consistent with the proposed role of HDL in reverse cholesterol transport. Curr Opin Lipidol 10:309-314, (C) 1999 Lippincott Williams & Wilkins.
引用
收藏
页码:309 / 314
页数:6
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