Diagnostic value of minor salivary glands biopsy for the detection of Lewy pathology

被引：34

作者：

Folgoas, Emmanuelle ^{[1
]}

Lebouvier, Thibaud ^{[1
,2
]}

Leclair-Visonneau, Laurene ^{[2
,3
]}

Cersosimo, Maria-Graciela ^{[4
]}

Barthelaix, Annick ^{[5
,6
]}

Derkinderen, Pascal ^{[1
,2
]}

Letournel, Franck ^{[5
,6
]}

机构：

[1] CHU Nantes, Dept Neurol, F-44093 Nantes, France

[2] INSERM, U913, F-44093 Nantes, France

[3] CHU Nantes, Dept Physiol, F-44093 Nantes, France

[4] Univ Buenos Aires, Parkinsons Dis & Movement Disorder Unit, Hosp Clin, RA-1053 Buenos Aires, DF, Argentina

[5] CHU Angers, Neuobiol & Neuropathol Lab, F-49033 Angers, France

[6] Univ Angers, UPRES EA3143, F-49033 Angers, France

来源：

NEUROSCIENCE LETTERS | 2013年 / 551卷

关键词：

Parkinson's disease; Salivary glands; Minor salivary glands biopsy; Lewy bodies; Lewy neurites; Alpha-synuclein;

D O I：

10.1016/j.neulet.2013.07.016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The recent demonstration of the presence of Lewy pathology in the submandibular glands of Parkinson's disease (PD) patients prompted us to evaluate the diagnostic performance of minor salivary gland biopsy for PD. Minor salivary glands were examined for Lewy pathology using phosphorylated alpha-synuclein antibody in 16 patients with clinically diagnosed PD and 11 control subjects with other neurological disorders. Abnormal accumulation of alpha-synuclein was found in 3 out of 16 PD patients. Two control subjects exhibited weak phosphorylated alpha-synuclein immunoreactivity. Our results do not support the use of minor salivary glands biopsy for the detection of Lewy pathology in living subjects. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：62 / 64

页数：3

共 17 条

[1] Submandibular Gland Biopsy for the Diagnosis of Parkinson Disease [J].