Palladium-Catalyzed Catellani Aminocyclopropanation Reactions with Vinyl Halides

被引：21
作者：
Khanna, Avinash [1 ]
Premachandra, Ilandari Dewage Udara Anulal [1 ]
Sung, Paul D. [1 ]
Van Vranken, David L. [1 ]
机构：
[1] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 12期
基金：
美国国家科学基金会;
关键词：
CYCLOPROPANATION; ALKENES; REACTIVITY; DERIVATIVES; AMINATION; MECHANISM; PATHWAYS; KEY;
D O I：
10.1021/ol401383m
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Palladium is shown to catalyze an Intramolecular aminocyclopropanation of norbornenes with aliphatic vinyl halides In good yields. The reaction tolerates a variety of amine substituents and gives good results with a variety of carbocyclic and oxabicyclic [2.2.1] alkene acceptors. Notably, stabilized enolate nucleophiles were also employed in cyclopropanation reactions.
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页码：3158 / 3161
页数：4
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