Two Cu(II) complexes: inhibitory activity on ovarian cancer cell proliferation, migration, and invasion ability via increasing miRNA16 expression

Two new Cu(II)-based coordination polymers (CPs) {[Cu-3(btc)(2)(bpfp)(2)(H2O)(2)](H2O)(2)}(n)(1, H(3)btc=1,2,3-benzenetricarboxylic acid, bpfp=bis(4-pyridylformyl)piperazine) and {[Cu(cca)(bpfp)]center dot 2H(2)O}(n)(2, H(2)cca = 2-carboxycinnamic acid) have been successfully prepared by reaction of Cu(NO3)(2)center dot 3H(2)O with the bpfp ligand in the presence of different carboxylate ligands. Compounds1and2were synthesized for the evaluation of anti-cancer activity on the ovarian cancer cells CoC1. First of all, the cancer cell proliferation, migration and invasion ability were determined. Subsequently, the marker of the ovarian cancer cells-miRNA16 was also measured with real time reverse transcription-polymerase chain reaction (RT-PCR).